Reactome | CLEC10A [plasma membrane]

CLEC10A [plasma membrane]

Stable Identifier

R-HSA-1472863

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

C-type lectin domain family 10 member A, CLC10_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9H115

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External Reference Information

External Reference

UniProt:Q8IUN9 CLEC10A

Gene Names

CLEC10A, CLECSF13, CLECSF14, HML

Chain

chain:1-316

Reference Genes

BioGPS Gene:10462 CLEC10A

COSMIC (genes):CLEC10A CLEC10A

CTD Gene:10462 CLEC10A

dbSNP Gene:10462 CLEC10A

ENSEMBL:ENSG00000132514 CLEC10A

ENSEMBL_homo_sapiens_GENE:ENSG00000132514.14 CLEC10A

HGNC:16916 CLEC10A

KEGG Gene (Homo sapiens):10462 CLEC10A

Monarch:10462 CLEC10A

NCBI Gene:10462 CLEC10A

OMIM:605999 CLEC10A

UCSC:Q8IUN9 CLEC10A

Reference Transcript

Other Identifiers

10462

11740531_a_at

11745500_a_at

11760018_at

16840473

206682_PM_at

206682_at

33569_at

3743312

3743313

3743314

3743315

3743316

3743317

3743318

3743319

3743320

3743321

3743322

3743323

3743324

3743325

3743326

3743327

3743328

3743329

8012013

A_23_P141505

A_23_P141508

D50532_at

GE81625

GO:0002250

GO:0002376

GO:0005515

GO:0005537

GO:0005886

GO:0006897

GO:0009897

GO:0016020

GO:0016192

GO:0030246

GO:0042806

GO:0045087

GO:0098542

ILMN_1653166

ILMN_1704797

ILMN_2415303

PH_hs_0003557

PH_hs_0035431

TC17001074.hg

g5453683_3p_at

Participates

as a component of

CLEC10A:Tn antigens [plasma membrane] (Homo sapiens)

as an input of

CLEC10A binds Tn-MUC1 (Homo sapiens)

Inferred To

si:ch211-125e6.12 [plasma membrane] (Danio rerio)

tfc [plasma membrane] (Drosophila melanogaster)

clec-196 [plasma membrane] (Caenorhabditis elegans)

clec-266 [plasma membrane] (Caenorhabditis elegans)

lectin-37Da [plasma membrane] (Drosophila melanogaster)

LOC116412330 [plasma membrane] (Xenopus tropicalis)

si:ch211-154o6.6 [plasma membrane] (Danio rerio)

CLEC10A [plasma membrane] (Bos taurus)

CLEC10A [plasma membrane] (Caenorhabditis elegans)

CLEC10A [plasma membrane] (Gallus gallus)

lectin-24Db [plasma membrane] (Drosophila melanogaster)

lectin-21Ca [plasma membrane] (Drosophila melanogaster)

lectin-29Ca [plasma membrane] (Drosophila melanogaster)

clec-91 [plasma membrane] (Caenorhabditis elegans)

clec-199 [plasma membrane] (Caenorhabditis elegans)

asgr1a [plasma membrane] (Danio rerio)

lectin-24A [plasma membrane] (Drosophila melanogaster)

clec-47 [plasma membrane] (Caenorhabditis elegans)

nw [plasma membrane] (Drosophila melanogaster)

clec-87 [plasma membrane] (Caenorhabditis elegans)

clec-86 [plasma membrane] (Caenorhabditis elegans)

Dmel\CG12111 [plasma membrane] (Drosophila melanogaster)

Sfp24F [plasma membrane] (Drosophila melanogaster)

BEST:GH10831 [plasma membrane] (Drosophila melanogaster)

clec-149 [plasma membrane] (Caenorhabditis elegans)

clec-224 [plasma membrane] (Caenorhabditis elegans)

clec-204 [plasma membrane] (Caenorhabditis elegans)

CR14499 [plasma membrane] (Drosophila melanogaster)

Dmel\CG14500 [plasma membrane] (Drosophila melanogaster)

clec-88 [plasma membrane] (Caenorhabditis elegans)

clec-202 [plasma membrane] (Caenorhabditis elegans)

Dmel\CG14866 [plasma membrane] (Drosophila melanogaster)

clec-45 [plasma membrane] (Caenorhabditis elegans)

lectin-21Cb [plasma membrane] (Drosophila melanogaster)

Dmel\CG15818 [plasma membrane] (Drosophila melanogaster)

Lectin-galC1 [plasma membrane] (Drosophila melanogaster)

lectin-22C [plasma membrane] (Drosophila melanogaster)

Dmel\CG43055 [plasma membrane] (Drosophila melanogaster)

Homologues of CLEC10A [plasma membrane] (Caenorhabditis elegans)

Homologues of CLEC10A [plasma membrane] (Danio rerio)

Homologues of CLEC10A [plasma membrane] (Drosophila melanogaster)

Homologues of CLEC10A [plasma membrane] (Gallus gallus)

lectin-37Db [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_006335.2, NP_878910.1

OpenTargets

ENSG00000132514

GeneCards

Q8IUN9

HPA

ENSG00000132514-CLEC10A

Ensembl

ENST00000571664, ENSP00000460252, ENST00000576617, ENST00000254868, ENSG00000132514, ENSP00000458728, ENSP00000254868

PRO

Q8IUN9

Pharos - Targets

Q8IUN9

HMDB Protein

HMDBP07587

PDB

6XIY, 6PUV, 6PY1, 6W12

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.623	4
UniProt:Q8WWP7 GIMA1			0.601	4
UniProt:Q13021 MALL			0.556	3
UniProt:O60831 PRAF2			0.556	3
UniProt:Q96MV8 ZDH15			0.556	3
UniProt:Q9NWW5 CLN6			0.556	3
UniProt:Q9NRQ5 SMCO4			0.556	3
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.556	5
UniProt:P30536 TSPO	1	TSPO [mitochondrial outer membrane] (R-HSA-2980957)	0.556	3
UniProt:Q5BVD1 TTMP			0.556	3
UniProt:A2RU14 TM218			0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3
UniProt:Q53HI1 UNC50			0.556	3
UniProt:A5PKU2 A5PKU2			0.556	3
UniProt:Q9H0Q3 FXYD6	1	FXYD6 [plasma membrane] (R-HSA-2752104)	0.556	3
UniProt:Q9Y5Y5 PEX16	2	PEX16 [peroxisomal membrane] (R-HSA-9603805) PEX16 [cytosol] (R-HSA-9603790)	0.556	3
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.556	3
UniProt:O15155 BET1	3	BET1 [Golgi membrane] (R-HSA-6807743) BET1 [transport vesicle] (R-HSA-6808719) BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142)	0.556	3
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.556	3
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.556	3
UniProt:Q9NVC3 S38A7			0.556	3
UniProt:O95159 ZFPL1			0.556	3
UniProt:Q6UX27-3 VSTM1			0.556	3
UniProt:P31513 FMO3	6	FMO3 M66I [endoplasmic reticulum membrane] (R-HSA-5603010) FMO3 E32K [endoplasmic reticulum membrane] (R-HSA-5602848) FMO3 R492W [endoplasmic reticulum membrane] (R-HSA-5602849) FMO3 N61S [endoplasmic reticulum membrane] (R-HSA-5602964) FMO3 P153L [endoplasmic reticulum membrane] (R-HSA-5602837) FMO3 [endoplasmic reticulum membrane] (R-HSA-54929)	0.556	3

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