Carbonic anhydrase hydrates carbon dioxide (mitochondria)

Stable Identifier
R-HSA-1475032
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Carbonic anhydrase VA (CA5A, Nagao et al. 1993, Franchi et al. 2003, Nishimori et al. 2007) and carbonic anhydrase VB (CA5B, Fujikawa-Adachi et al. 1999, Nishimori et al. 2005, Nishimori et al. 2007) hydrate carbon dioxide in mitochondria to yield bicarbonate and a proton. Carbonic anhydrase deprotonates water to yield a zinc-hydroxyl group and a proton which is transferred to external buffer molecules via histidine or glutamate residues in carbonic anhydrase. The hydroxyl group reacts with carbon dioxide in the active site to yield bicarbonate. A water molecule displaces the bicarbonate and the reaction cycle begins again (reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible.

Literature References
PubMed ID Title Journal Year
16302824 Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors

Nishimori, I, Vullo, D, Innocenti, A, Scozzafava, A, Mastrolorenzo, A, Supuran, CT

J Med Chem 2005
10409679 Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome x

Fujikawa-Adachi, K, Nishimori, I, Taguchi, T, Onishi, S

J Biol Chem 1999
8356065 Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16

Nagao, Y, Platero, JS, Waheed, A, Sly, WS

Proc Natl Acad Sci U S A 1993
17761422 Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different

Nishimori, I, Innocenti, A, Vullo, D, Scozzafava, A, Supuran, CT

Bioorg Med Chem 2007
14611844 Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anions

Franchi, M, Vullo, D, Gallori, E, Antel, J, Wurl, M, Scozzafava, A, Supuran, CT

Bioorg Med Chem Lett 2003
9336012 Structure and mechanism of carbonic anhydrase

Lindskog, S

Pharmacol Ther 1997
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
carbonate dehydratase activity of CA5A,B:Zinc [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created