1-acyl LPA is acylated to PA by AGPAT5 (OM)

Stable Identifier
R-HSA-1482548
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane, cytosol
ReviewStatus
5/5
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1-acyl LPA is acylated to PA by AGPAT5 (OM)
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At the outer mitochondrial (OM) membrane, 1-acyl lysophosphatidic acid (LPA) is acylated to phosphatidic acid (PA) by the enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferases epsilon (AGPAT5) (Prasad et al. 2011).
Literature References
PubMed ID Title Journal Year
21173190 Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria

Prasad, SS, Agarwal, AK, Garg, A

J Lipid Res 2011
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Output
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Catalyst Activity

1-acylglycerol-3-phosphate O-acyltransferase activity of AGPAT5 [mitochondrial outer membrane]

Physical Entity
AGPAT5 [mitochondrial outer membrane] (Homo sapiens)
Activity
1-acylglycerol-3-phosphate O-acyltransferase activity (GO:0003841)
Orthologous Events
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Bos taurus)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Caenorhabditis elegans)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Canis familiaris)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Dictyostelium discoideum)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Gallus gallus)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Mus musculus)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Rattus norvegicus)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Sus scrofa)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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