2-acyl LPC is hydrolyzed to GPCho by PLA2[8]

Stable Identifier
R-HSA-1482612
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, 2-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.

Literature References
PubMed ID Title Journal Year
15944408 Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)

Yamashita, A, Kamata, R, Kawagishi, N, Nakanishi, H, Suzuki, H, Sugiura, T, Waku, K

J Biochem 2005
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
19019078 The identification of a phospholipase B precursor in human neutrophils

Xu, S, Zhao, L, Larsson, A, Venge, P

FEBS J 2009
19501189 Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)

Yamashita, A, Tanaka, K, Kamata, R, Kumazawa, T, Suzuki, N, Koga, H, Waku, K, Sugiura, T

Biochim Biophys Acta 2009
8083230 Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2

Sharp, JD, Pickard, RT, Chiou, XG, Manetta, JV, Kovacevic, S, Miller, JR, Varshavsky, AD, Roberts, EF, Strifler, BA, Brems, DN

J Biol Chem 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lysophospholipase activity of PLA2(8) [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created
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