1-acyl LPC is hydrolyzed to GPCho by PLA2G4C

Stable Identifier
R-HSA-1482696
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, 1-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by membrane-bound cytosolic phospholipase A2 gamma (PLA2G4C) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009).

Literature References
PubMed ID Title Journal Year
15944408 Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)

Yamashita, A, Kamata, R, Kawagishi, N, Nakanishi, H, Suzuki, H, Sugiura, T, Waku, K

J Biochem 2005
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
19501189 Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)

Yamashita, A, Tanaka, K, Kamata, R, Kumazawa, T, Suzuki, N, Koga, H, Waku, K, Sugiura, T

Biochim Biophys Acta 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lysophospholipase activity of PLA2G4C [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created
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