PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)

Stable Identifier
R-HSA-1482745
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the inner mitochondrial membrane (IM), phosphatidylglycerol (PG) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 beta (PLA2G4B) to form 1-acyl lysophosphatidylglycerol (LPG) (Ghomashchi et al. 2010, Singer et al. 2002).

Literature References
PubMed ID Title Journal Year
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Singer, AG, Ghomashchi, F, Le Calvez, C, Bollinger, J, Bezzine, S, Rouault, M, Sadilek, M, Nguyen, E, Lazdunski, M, Lambeau, G, Gelb, MH

J Biol Chem 2002
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phospholipase A2 activity of PLA2G [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created