Acyl chain remodelling of PE

Stable Identifier
R-HSA-1482839
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

In the acyl chain remodelling pathway (Lands cycle), phosphatidylethanolamine (PE) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane (Ghomashchi et al. 2010, Singer et al. 2002, Cao et al. 2008, Zhao et al. 2008, Hishikawa et al. 2008).

Literature References
PubMed ID Title Journal Year
18195019 Identification and characterization of a major liver lysophosphatidylcholine acyltransferase

Zhao, Y, Chen, YQ, Bonacci, TM, Bredt, DS, Li, S, Bensch, WR, Moller, DE, Kowala, M, Konrad, RJ, Cao, G

J Biol Chem 2008
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
18458083 Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2

Cao, J, Shan, D, Revett, T, Li, D, Wu, L, Liu, W, Tobin, JF, Gimeno, RE

J Biol Chem 2008
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Singer, AG, Ghomashchi, F, Le Calvez, C, Bollinger, J, Bezzine, S, Rouault, M, Sadilek, M, Nguyen, E, Lazdunski, M, Lambeau, G, Gelb, MH

J Biol Chem 2002
18287005 Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity

Hishikawa, D, Shindou, H, Kobayashi, S, Nakanishi, H, Taguchi, R, Shimizu, T

Proc Natl Acad Sci U S A 2008
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created