PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)

Stable Identifier
R-HSA-1482847
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the inner mitochondrial (IR) membrane, phosphatidylglycerol (PG) is hydrolysed, and has one of its acyl chains cleaved off, by phospholipase A2 beta (PLA2G4B) (Ghomashchi et al. 2010) to form 2-acyl lysophosphatidylglycerol (LPG). Phospholipase A2 enzymes show not only PLA2 hydrolysing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.

Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phospholipase A1 activity of PLA2G [mitochondrial inner membrane]
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Activity
Orthologous Events
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Created