Hydrolysis of LPC

Stable Identifier
R-HSA-1483115
Type
Pathway
Species
Homo sapiens
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Hydrolysis of LPC
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Lysophosphatidylcholine (LPC) is hydrolyzed by phospholipases to produce glycerophosphocholine (GPCho) which is in turn hydrolyzed by glycerophosphocholine phosphodiesterase to produce choline (Cho) and glycerol-3-phosphate (G3P) (Yamashita et al. 2009, Yamashita et al. 2005, Ghomashchi et al. 2010).

Literature References
PubMed ID Title Journal Year
15944408 Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)

Yamashita, A, Kamata, R, Kawagishi, N, Nakanishi, H, Suzuki, H, Sugiura, T, Waku, K

J Biochem 2005
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
19501189 Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)

Yamashita, A, Tanaka, K, Kamata, R, Kumazawa, T, Suzuki, N, Koga, H, Waku, K, Sugiura, T

Biochim Biophys Acta 2009
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
phospholipid metabolic process (0006644)
Orthologous Events
Hydrolysis of LPC (Bos taurus)
Hydrolysis of LPC (Caenorhabditis elegans)
Hydrolysis of LPC (Canis familiaris)
Hydrolysis of LPC (Danio rerio)
Hydrolysis of LPC (Dictyostelium discoideum)
Hydrolysis of LPC (Drosophila melanogaster)
Hydrolysis of LPC (Gallus gallus)
Hydrolysis of LPC (Mus musculus)
Hydrolysis of LPC (Plasmodium falciparum)
Hydrolysis of LPC (Rattus norvegicus)
Hydrolysis of LPC (Saccharomyces cerevisiae)
Hydrolysis of LPC (Schizosaccharomyces pombe)
Hydrolysis of LPC (Sus scrofa)
Hydrolysis of LPC (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-08-12)