GPCho is hydrolyzed to Cho and G3P by GPCPD1

Stable Identifier
R-HSA-1483116
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the cytosol, glycerophosphocholine phosphodiesterase (GPCPD1, also known as GDE5) hydrolyzes glycerophosphocholine (GPCho) to produce choline (Cho) and glycerol-3-phosphate (G3P). This event has been inferred from mice. GPCPD1 has also been characterized in humans (Ota et al. 2004).

Literature References
PubMed ID Title Journal Year
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota, T, Suzuki, Y, Nishikawa, T, Otsuki, T, Sugiyama, T, Irie, R, Wakamatsu, A, Hayashi, K, Sato, H, Nagai, K, Kimura, K, Makita, H, Sekine, M, Obayashi, M, Nishi, T, Shibahara, T, Tanaka, T, Ishii, S, Yamamoto, J, Saito, K, Kawai, Y, Isono, Y, Nakamura, Y, Nagahari, K, Murakami, K, Yasuda, T, Iwayanagi, T, Wagatsuma, M, Shiratori, A, Sudo, H, Hosoiri, T, Kaku, Y, Kodaira, H, Kondo, H, Sugawara, M, Takahashi, M, Kanda, K, Yokoi, T, Furuya, T, Kikkawa, E, Omura, Y, Abe, K, Kamihara, K, Katsuta, N, Sato, K, Tanikawa, M, Yamazaki, M, Ninomiya, K, Ishibashi, T, Yamashita, H, Murakawa, K, Fujimori, K, Tanai, H, Kimata, M, Watanabe, M, Hiraoka, S, Chiba, Y, Ishida, S, Ono, Y, Takiguchi, S, Watanabe, S, Yosida, M, Hotuta, T, Kusano, J, Kanehori, K, Takahashi-Fujii, A, Hara, H, Tanase, TO, Nomura, Y, Togiya, S, Komai, F, Hara, R, Takeuchi, K, Arita, M, Imose, N, Musashino, K, Yuuki, H, Oshima, A, Sasaki, N, Aotsuka, S, Yoshikawa, Y, Matsunawa, H, Ichihara, T, Shiohata, N, Sano, S, Moriya, S, Momiyama, H, Satoh, N, Takami, S, Terashima, Y, Suzuki, O, Nakagawa, S, Senoh, A, Mizoguchi, H, Goto, Y, Shimizu, F, Wakebe, H, Hishigaki, H, Watanabe, T, Sugiyama, A, Takemoto, M, Kawakami, B, Yamazaki, M, Watanabe, K, Kumagai, A, Itakura, S, Fukuzumi, Y, Fujimori, Y, Komiyama, M, Tashiro, H, Tanigami, A, Fujiwara, T, Ono, T, Yamada, K, Fujii, Y, Ozaki, K, Hirao, M, Ohmori, Y, Kawabata, A, Hikiji, T, Kobatake, N, Inagaki, H, Ikema, Y, Okamoto, S, Okitani, R, Kawakami, T, Noguchi, S, Itoh, T, Shigeta, K, Senba, T, Matsumura, K, Nakajima, Y, Mizuno, T, Morinaga, M, Sasaki, M, Togashi, T, Oyama, M, Hata, H, Watanabe, M, Komatsu, T, Mizushima-Sugano, J, Satoh, T, Shirai, Y, Takahashi, Y, Nakagawa, K, Okumura, K, Nagase, T, Nomura, N, Kikuchi, H, Masuho, Y, Yamashita, R, Nakai, K, Yada, T, Nakamura, Y, Ohara, O, Isogai, T, Sugano, S

Nat Genet 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycerophosphodiester phosphodiesterase activity of GPCPD1 [cytosol]
Physical Entity
Activity
Inferred From
Cross References
Rhea
Authored
Created
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