PI and PC transport between ER and Golgi membranes

Stable Identifier
R-HSA-1483196
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Pathway
Species
Homo sapiens
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The phosphatidylinositol transfer protein beta isoform (PITPNB) bound to phosphatidylinositol (PI) complex transports from the endoplasmic reticulum (ER) membrane to the Golgi membrane, where phosphatidylcholine (PC) is exchanged for PI. PITPNB now in complex with PC transports back to the ER membrane where PI is now exchanged for PC, and the cycle repeats. This process has been characterized in detail in bovine and rodent model systems (e.g., Wirtz et al. 2006; Ghosh and Bankaitis 2011), which provide a framework for organizing the more limited data available for the very well conserved human proteins and processes( Carvou et al. 2010, Shadan et al. 2008).

Literature References
PubMed ID Title Journal Year
18636990 Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells

Shadan, S, Holic, R, Carvou, N, Ee, P, Li, M, Murray-Rust, J, Cockcroft, S

Traffic 2008
21915936 Phosphatidylinositol transfer proteins: negotiating the regulatory interface between lipid metabolism and lipid signaling in diverse cellular processes

Ghosh, R, Bankaitis, VA

Biofactors 2011
16854452 Phosphatidylinositol transfer proteins: from closed for transport to open for exchange

Wirtz, KWA, Schouten, A, Gros, P

Adv Enzyme Regul 2006
20332109 Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum

Carvou, N, Holic, R, Li, M, Futter, C, Skippen, A, Cockcroft, S

J Cell Sci 2010
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