PTPMT1 dephosphorylates PGP to PG

Stable Identifier
R-HSA-1483197
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the inner mitochondrial (IM) membrane, PTPMT1 (phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1) catalyzes the dephosphorylation of phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). The biochemical properties of human PTPMT1 have not been determined; this reaction is inferred from the one catalyzed by the homologous mouse protein (Zhang et al. 2011).

Literature References
PubMed ID Title Journal Year
21641550 Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis

Zhang, J, Guan, Z, Murphy, AN, Wiley, SE, Perkins, GA, Worby, CA, Engel, JL, Heacock, P, Nguyen, OK, Wang, JH, Raetz, CR, Dowhan, W, Dixon, JE

Cell Metab. 2011
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidylglycerophosphatase activity of PTPMT1 [mitochondrial inner membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created