PA is dephosphorylated to DAG by LPIN

Stable Identifier
R-HSA-1483203
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

At the endoplasmic reticulum (ER) membrane, phosphatidate phosphatase 1-3 (LPIN) dephosphorylates phosphatidic acid (PA) to form diacylglycerol (DAG) (Grimsey et al. 2008, Donkor et al. 2007).

Literature References
PubMed ID Title Journal Year
17158099 Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns

Donkor, J, Sariahmetoglu, M, Dewald, J, Brindley, DN, Reue, K

J Biol Chem 2007
18694939 Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2

Grimsey, N, Han, GS, O'Hara, L, Rochford, JJ, Carman, GM, Siniossoglou, S

J Biol Chem 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidate phosphatase activity of LPIN [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored