PG is converted to BMP

Stable Identifier
R-HSA-1483209
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
late endosome membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PG is converted to BMP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The biosynthetic pathway of lysobisphosphatidic acid, also known as bis(monoacylglycerol) hydrogen phosphate (BMP), is still not fully understood with the in vivo enzymes responsible yet to be fully identified. It appears to involve multiple steps including hydrolysis of phosphatidylglycerol (PG) by a phospholipase A2, acylation, and a reorientation of the phosphoryl ester (Poorthuis & Hostetler 1978, Heravi & Waite 1999, Hullin-Matsuda et al. 2007, Gallala & Sandhoff 2010).
Literature References
PubMed ID Title Journal Year
21136156 Biological Function of the Cellular Lipid BMP-BMP as a Key Activator for Cholesterol Sorting and Membrane Digestion

Gallala, HD, Sandhoff, K

Neurochem Res 2010
10101262 Transacylase formation of bis(monoacylglycerol)phosphate

Waite, M, Heravi, J

Biochim Biophys Acta 1999
650089 Conversion of diphosphatidylglycerol to bis(monoacylglyceryl)phosphate by lysosomes

Hostetler, KY, Poorthuis, BJ

J Lipid Res 1978
17558022 De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate

Lagarde, M, Schlame, M, Kobayashi, T, Xu, Y, Kawasaki, K, Hullin-Matsuda, F, Nishijima, M, Delton-Vandenbroucke, I

J Lipid Res 2007
Participants
Input
Output
Participates
as an event of
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
Cite Us!