PS is decarboxylated to PE by PISD

Stable Identifier
R-HSA-1483212
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the inner mitochondrial (IM) membrane, phosphatidylserine decarboxylase proenzyme (heterodimer of two chains from the same protein) (PISD) decarboxylates phosphatidylserine (PS) to phosphatidylethanolamine (PE). This event has been inferred from rats and limited data for a human PISD (Forbes et al. 2007).

Literature References
PubMed ID Title Journal Year
17478478 High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase

Forbes, CD, Toth, JG, Ozbal, CC, Lamarr, WA, Pendleton, JA, Rocks, S, Gedrich, RW, Osterman, DG, Landro, JA, Lumb, KJ

J Biomol Screen 2007
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidylserine decarboxylase activity of PISD:Pyruvoyl [mitochondrial inner membrane]
Physical Entity
Activity
Inferred From
Authored
Created
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