DAG and IP3 signaling

Stable Identifier
R-HSA-1489509
Type
Pathway
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
Locations in the PathwayBrowser
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Summation

This pathway describes the generation of DAG and IP3 by the PLCgamma-mediated hydrolysis of PIP2 and the subsequent downstream signaling events.

Literature References
PubMed ID Title Journal Year
16260143 Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling

Patterson, RL, van Rossum, DB, Nikolaidis, N, Gill, DL, Snyder, SH

Trends Biochem Sci 2005
Participants
Events
Participant Of
hasEvent
Orthologous Events
DAG and IP3 signaling (Arabidopsis thaliana)
DAG and IP3 signaling (Bos taurus)
DAG and IP3 signaling (Caenorhabditis elegans)
DAG and IP3 signaling (Canis familiaris)
DAG and IP3 signaling (Danio rerio)
DAG and IP3 signaling (Dictyostelium discoideum)
DAG and IP3 signaling (Drosophila melanogaster)
DAG and IP3 signaling (Gallus gallus)
DAG and IP3 signaling (Mus musculus)
DAG and IP3 signaling (Oryza sativa)
DAG and IP3 signaling (Plasmodium falciparum)
DAG and IP3 signaling (Rattus norvegicus)
DAG and IP3 signaling (Saccharomyces cerevisiae)
DAG and IP3 signaling (Sus scrofa)
DAG and IP3 signaling (Taeniopygia guttata)
DAG and IP3 signaling (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)