DAG and IP3 signaling

Summation

This pathway describes the generation of DAG and IP3 by the PLCgamma-mediated hydrolysis of PIP2 and the subsequent downstream signaling events.

Participants

Events

• Active PLCG1 hydrolyses PIP2 (Homo sapiens)
• DAG stimulates protein kinase C-delta (Homo sapiens)
• IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
• IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
• CaM pathway (Homo sapiens)

Participant Of

hasEvent

• Intracellular signaling by second messengers

Orthologous Events

DAG and IP3 signaling (Arabidopsis thaliana)

DAG and IP3 signaling (Bos taurus)

DAG and IP3 signaling (Caenorhabditis elegans)

DAG and IP3 signaling (Canis familiaris)

DAG and IP3 signaling (Danio rerio)

DAG and IP3 signaling (Dictyostelium discoideum)

DAG and IP3 signaling (Drosophila melanogaster)

DAG and IP3 signaling (Gallus gallus)

DAG and IP3 signaling (Mus musculus)

DAG and IP3 signaling (Oryza sativa)

DAG and IP3 signaling (Plasmodium falciparum)

DAG and IP3 signaling (Rattus norvegicus)

DAG and IP3 signaling (Saccharomyces cerevisiae)

DAG and IP3 signaling (Sus scrofa)

DAG and IP3 signaling (Taeniopygia guttata)

DAG and IP3 signaling (Xenopus tropicalis)

Authored

Nasi, S  (2006-10-10)

Annibali, D  (2006-10-10)

Reviewed

Greene, LA  (2007-11-08)

Created

Rothfels, K  (2011-08-15)