Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-S213-SPR [cytosol]
Stable Identifier
R-HSA-1497782
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Sepiapterin reductase, SPRE_HUMAN, SPR
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)
p-SPR dimer [cytosol] (Homo sapiens)
p-S213-SPR [cytosol] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Homo sapiens)
p-SPR dimer [cytosol] (Homo sapiens)
p-S213-SPR [cytosol] (Homo sapiens)
Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)
p-SPR dimer [cytosol] (Homo sapiens)
p-S213-SPR [cytosol] (Homo sapiens)
Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Homo sapiens)
p-SPR dimer [cytosol] (Homo sapiens)
p-S213-SPR [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35270 SPR
Gene Names
SPR
Chain
chain:1-261
Reference Genes
BioGPS Gene:6697 SPR
COSMIC (genes):SPR SPR
CTD Gene:6697 SPR
dbSNP Gene:6697 SPR
ENSEMBL:ENSG00000116096 SPR
ENSEMBL_homo_sapiens_GENE:ENSG00000116096.6 SPR
HGNC:11257 SPR
KEGG Gene (Homo sapiens):6697 SPR
Monarch:6697 SPR
NCBI Gene:6697 SPR
OMIM:182125 SPR
UCSC:P35270 SPR
Reference Transcript
RefSeq:NM_003124.4 SPR
Other Identifiers
11718640_at
16881434
203458_PM_at
203458_at
2488585
2488586
2488588
2488589
2488590
2488592
2488593
32108_at
6697
73051_i_at
73052_f_at
8042696
A_14_P105143
A_23_P68211
GE58077
GO:0003824
GO:0004033
GO:0004757
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006729
GO:0006809
GO:0016491
GO:0043226
GO:0050661
GO:0070062
HMNXSV003018505
Hs.301540.0.S2_3p_at
ILMN_1705849
M76231_at
TC02000435.hg
Participates
as a component of
p-SPR dimer [cytosol] (Homo sapiens)
Other forms of this molecule
SPR [cytosol]
Inferred To
phospho-spr [cytosol]
(Xenopus tropicalis)
phospho-Sptr [cytosol]
(Drosophila melanogaster)
phospho-p-S213-SPR [cytosol]
(Dictyostelium discoideum)
phospho-p-S213-SPR [cytosol]
(Gallus gallus)
phospho-p-S213-SPR [cytosol]
(Mus musculus)
phospho-p-S213-SPR [cytosol]
(Rattus norvegicus)
phospho-LOC795445 [cytosol]
(Danio rerio)
phospho-SPR [cytosol]
(Bos taurus)
phospho-SPR [cytosol]
(Canis familiaris)
phospho-SPR [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 213
Coordinate
213
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_003115.1
Guide to Pharmacology - Targets
3020
OpenTargets
ENSG00000116096
HPA
ENSG00000116096-SPR
GeneCards
P35270
Ensembl
ENSG00000116096
,
ENST00000234454
,
ENSP00000234454
PRO
P35270
Pharos - Targets
P35270
Orphanet
15551
HMDB Protein
HMDBP00436
PDB
6I6P
,
4J7X
,
6I6V
,
6I6T
,
4J7U
,
4Z3K
,
6I79
,
7DSF
,
6I6F
,
4XWY
,
1Z6Z
,
6I6C
,
4HWK
,
6USN
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text