Reactome | Salvage - BH2 is reduced to BH4 by DHFR

Salvage - BH2 is reduced to BH4 by DHFR

Stable Identifier

R-HSA-1497794

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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In the second salvage step, dihydrofolate reductase (DHFR) can regenerate BH4 from BH2, a process which increases the BH4:BH2 ratio providing BH4 for coupled eNOS production of NO. In mice cell lines, DHFR inhibition or knockdown diminishes the BH4:BH2 ratio and exacerbates eNOS uncoupling (Crabtree et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19666465	Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways Hale, AB, Tatham, AL, Channon, KM, Alp, NJ, Crabtree, MJ	J Biol Chem	2009

Participants

Input

Output

Participates

as an event of

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)

Catalyst Activity

dihydrofolate reductase activity of DHFR dimer [cytosol]

Physical Entity

DHFR dimer [cytosol] (Homo sapiens)

Activity

dihydrofolate reductase activity (GO:0004146)

Inferred From

Salvage - BH2 is reduced to BH4 by Dhfr (Mus musculus)

Authored

Jassal, B (2011-08-17)

Reviewed

D'Eustachio, P (2011-08-23)

Created

Jassal, B (2011-08-17)

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