The oxidation product of BH4, 7,8-dihydrobiopterin (BH2), can compete with BH4 for binding to eNOS. This can lead to the uncoupling of eNOS and can result in the formation of reactive oxygen species (Vasquez-Vivar et al. 2002).
Vásquez-Vivar, J, Martasek, P, Whitsett, J, Joseph, J, Kalyanaraman, B
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