Reactome | BH2 binding can lead to eNOS uncoupling

BH2 binding can lead to eNOS uncoupling

Stable Identifier

R-HSA-1497796

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The oxidation product of BH4, 7,8-dihydrobiopterin (BH2), can compete with BH4 for binding to eNOS. This can lead to the uncoupling of eNOS and can result in the formation of reactive oxygen species (Vasquez-Vivar et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11879202	The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study Kalyanaraman, B, Joseph, J, Whitsett, J, Vásquez-Vivar, J, Martasek, P	Biochem J	2002