BH2 binding can lead to eNOS uncoupling

Stable Identifier
R-HSA-1497796
Type
Reaction [transition]
Species
Homo sapiens
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The oxidation product of BH4, 7,8-dihydrobiopterin (BH2), can compete with BH4 for binding to eNOS. This can lead to the uncoupling of eNOS and can result in the formation of reactive oxygen species (Vasquez-Vivar et al. 2002).

Literature References
PubMed ID Title Journal Year
11879202 The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study

Vásquez-Vivar, J, Martasek, P, Whitsett, J, Joseph, J, Kalyanaraman, B

Biochem J 2002
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