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BH2 binding can lead to eNOS uncoupling
Stable Identifier
R-HSA-1497796
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The oxidation product of BH4, 7,8-dihydrobiopterin (BH2), can compete with BH4 for binding to eNOS. This can lead to the uncoupling of eNOS and can result in the formation of reactive oxygen species (Vasquez-Vivar et al. 2002).
Literature References
PubMed ID
Title
Journal
Year
11879202
The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study
Kalyanaraman, B
,
Joseph, J
,
Whitsett, J
,
Vásquez-Vivar, J
,
Martasek, P
Biochem J
2002
Participants
Input
BH2 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
(Homo sapiens)
Output
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
Orthologous Events
BH2 binding can lead to eNOS uncoupling (Bos taurus)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
BH2 binding can lead to eNOS uncoupling (Mus musculus)
BH2 binding can lead to eNOS uncoupling (Plasmodium falciparum)
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
BH2 binding can lead to eNOS uncoupling (Sus scrofa)
Authored
Jassal, B (2011-08-17)
Reviewed
D'Eustachio, P (2011-08-23)
Created
Jassal, B (2011-08-17)
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