Uncoupled eNOS favours the formation of superoxide

Stable Identifier
R-HSA-1497810
Type
Reaction
Species
Homo sapiens
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BH2 may compete with BH4 to bind eNOS, uncoupling eNOS leading to the formation of superoxide rather than nitric oxide. BH2, the oxidised form of BH4, cannot contribute electrons to heme in the reductase domain of eNOS, thereby uncoupling it from arginine oxidation and producing superoxide from oxygen instead (Vasquez-Vivar et al. 2002).

Literature References
PubMed ID Title Journal Year
11879202 The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study

Vásquez-Vivar, J, Martasek, P, Whitsett, J, Joseph, J, Kalyanaraman, B

Biochem J 2002
Participants
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hasEvent
Catalyst Activity
Catalyst Activity
Title
superoxide-generating NADPH oxidase activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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