Salvage - Sepiapterin is reduced to BH2

Stable Identifier
R-HSA-1497869
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In the first of two salvage steps to maintain BH4 levels in the cell, sepiapterin is taken up by the cell and reduced by sepiapterin reductase (SRP) to form BH2 (Sawabe et al. 2008).
Literature References
PubMed ID Title Journal Year
18511317 Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin

Matsuoka, H, Sugawara, Y, Harada, Y, Sawabe, K, Hasegawa, H, Yamamoto, K, Ohashi, A

Mol Genet Metab 2008
Participants
Participates
Catalyst Activity

sepiapterin reductase activity of p-SPR dimer [cytosol]

Orthologous Events
Authored
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