Salvage - Sepiapterin is reduced to BH2

Stable Identifier
R-HSA-1497869
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the first of two salvage steps to maintain BH4 levels in the cell, sepiapterin is taken up by the cell and reduced by sepiapterin reductase (SRP) to form BH2 (Sawabe et al. 2008).

Literature References
PubMed ID Title Journal Year
18511317 Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin

Sawabe, K, Yamamoto, K, Harada, Y, Ohashi, A, Sugawara, Y, Matsuoka, H, Hasegawa, H

Mol Genet Metab 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sepiapterin reductase activity of p-SPR dimer [cytosol]
Physical Entity
Activity
Orthologous Events
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