Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)

Stable Identifier
R-HSA-1497878
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
nitric oxide + superoxide => peroxynitrite
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Superoxide (O2.-) formed from an uncoupled eNOS action, together with nitric oxide (NO) formed from a coupled eNOS action, readily react together to fom peroxynitrite (ONOO-) (Jourd'heuil et al. 2001, Reiter et al. 2000).
Literature References
PubMed ID Title Journal Year
10906340 Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite

Teng, RJ, Beckman, JS, Reiter, CD

J Biol Chem 2000
11373284 Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo

Grisham, MB, Musah, RA, Jourd'heuil, D, Wink, DA, Kutchukian, PS, Jourd'heuil, FL

J Biol Chem 2001
Participants
Input
Output
Participates
as an event of
Cross References
Rhea
RHEA
Authored
Jassal, B  (2011-08-17)
Reviewed
D'Eustachio, P  (2011-08-23)
Created
Jassal, B  (2011-08-17)
Cite Us!