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POMC(138-176) [cytosol]
Stable Identifier
R-HSA-1502544
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Corticotropin, ACTH, Adrenocorticotropic hormone
Icon
Locations in the PathwayBrowser for interactor UniProt:O75031
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP11B1 oxidises 11DCORT (Homo sapiens)
POMC(138-176) [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Metabolism of steroid hormones (Homo sapiens)
Androgen biosynthesis (Homo sapiens)
CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)
POMC(138-176) [cytosol] (Homo sapiens)
HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)
POMC(138-176) [cytosol] (Homo sapiens)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Homo sapiens)
POMC(138-176) [cytosol] (Homo sapiens)
SRD5A1 dehydrogenates TEST to DHTEST (Homo sapiens)
POMC(138-176) [cytosol] (Homo sapiens)
SRD5A2 dehydrogenates TEST to DHTEST (Homo sapiens)
POMC(138-176) [cytosol] (Homo sapiens)
SRD5A3 dehydrogenates TEST to DHTEST (Homo sapiens)
POMC(138-176) [cytosol] (Homo sapiens)
Glucocorticoid biosynthesis (Homo sapiens)
CYP11B1 oxidises 11DCORT (Homo sapiens)
POMC(138-176) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01189 POMC
Gene Names
POMC
Chain
signal peptide:1-26, peptide:27-102, peptide:77-87, peptide:105-134, peptide:138-176, peptide:138-150, peptide:156-176, peptide:179-267, peptide:179-234, peptide:217-234, peptide:237-267, peptide:237-241
Reference Genes
BioGPS Gene:5443 POMC
COSMIC (genes):POMC POMC
CTD Gene:5443 POMC
dbSNP Gene:5443 POMC
ENSEMBL:ENSG00000115138 POMC
ENSEMBL_homo_sapiens_GENE:ENSG00000115138.11 POMC
HGNC:9201 POMC
KEGG Gene (Homo sapiens):5443 POMC
Monarch:5443 POMC
NCBI Gene:5443 POMC
OMIM:176830 POMC
UCSC:P01189 POMC
Reference Transcript
RefSeq:NM_001035256.2 POMC
RefSeq:NM_001319205.1 POMC
RefSeq:NM_000939.3 POMC
RefSeq:NM_001319204.1 POMC
Other Identifiers
11716427_a_at
16895337
205720_PM_at
205720_at
2544631
2544632
2544633
2544634
2544635
2544636
2544637
2544638
2544639
2544640
2544641
2544643
2544644
2544647
33711_at
4126575
5443
8050805
A_23_P5875
A_33_P3345036
GE61306
GO:0001664
GO:0003013
GO:0005102
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005975
GO:0006091
GO:0006351
GO:0006355
GO:0007165
GO:0007218
GO:0007267
GO:0008217
GO:0019722
GO:0023052
GO:0030141
GO:0031410
GO:0031781
GO:0031782
GO:0032098
GO:0032720
GO:0033059
GO:0034774
GO:0042593
GO:0043226
GO:0043950
GO:0045944
GO:0048018
GO:0050886
GO:0070873
GO:0070996
GO:0098772
GO:0140668
GO:1990680
GO:2000852
HMNXSV003041514
ILMN_1672899
ILMN_2403664
PH_hs_0000252
TC02001657.hg
TC02004119.hg
V01510_rna1_at
g4505948_3p_at
This entity regulates
Positively
CYP11B1 oxidises 11DCORT
(Homo sapiens)
HSD17B3-like proteins reducde ANDST to TEST
(Homo sapiens)
SRD5A1 dehydrogenates TEST to DHTEST
(Homo sapiens)
SRD5A3 dehydrogenates TEST to DHTEST
(Homo sapiens)
SRD5A2 dehydrogenates TEST to DHTEST
(Homo sapiens)
CYP17A1 cleaves 17aHPREG to DHA
(Homo sapiens)
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST
(Homo sapiens)
Other forms of this molecule
POMC(138-176) [secretory granule lumen]
POMC(1-241) [secretory granule lumen]
POMC(138-176) R236G [extracellular region]
POMC(138-176) E79* [extracellular region]
POMC(138-176) K25* [extracellular region]
POMC(77-87) [extracellular region]
POMC(217-234) [extracellular region]
POMC(138-150) [extracellular region]
POMC(237-241) [extracellular region]
POMC(237-267) [extracellular region]
POMC(138-176) [extracellular region]
Inferred To
Pomc [cytosol]
(Mus musculus)
Pomc [cytosol]
(Rattus norvegicus)
POMC(138-176) [cytosol]
(Gallus gallus)
pomc [cytosol]
(Danio rerio)
pomc [cytosol]
(Xenopus tropicalis)
POMC [cytosol]
(Bos taurus)
POMC [cytosol]
(Canis familiaris)
POMC [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001030333.1
,
NP_001306133.1
,
NP_000930.1
,
NP_001306134.1
OpenTargets
ENSG00000115138
HPA
ENSG00000115138-POMC
GeneCards
P01189
Ensembl
ENST00000380794
,
ENSP00000384092
,
ENSP00000264708
,
ENSP00000370171
,
ENST00000405623
,
ENSG00000115138
,
ENST00000395826
,
ENST00000264708
,
ENSP00000379170
PRO
P01189
Pharos - Targets
P01189
Orphanet
16448
HMDB Protein
HMDBP12759
PDB
7PIV
,
6TUB
,
7F54
,
7F53
,
4Y49
,
8F7Q
,
4XNH
,
4XPD
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P2K6 KLHL42
1
KLHL42 [cytosol]
(R-HSA-8863204)
0.556
3
UniProt:Q9NX04 AIRIM
0.556
3
UniProt:O75031 HSF2B
0.556
6
UniProt:Q9UMX2-2 OAZ3
0.556
3
UniProt:Q8NI38 IKBD
0.556
3
UniProt:Q8N8Y2 ATP6V0D2
3
ATP6V0D2 [lysosomal membrane]
(R-HSA-9640179)
ATP6V0D2 [phagocytic vesicle membrane]
(R-HSA-1222586)
ATP6V0D2 [endosome membrane]
(R-HSA-912599)
0.556
3
UniProt:Q13064 MKRN3
0.556
3
UniProt:Q99757 TXN2
2
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
0.556
3
UniProt:Q7Z4H3 HDDC2
0.556
3
UniProt:Q68D86 C102B
0.556
3
UniProt:P51687 SUOX
1
SUOX [mitochondrial matrix]
(R-HSA-1614570)
0.556
3
UniProt:P62508-3 ESRRG
0.556
3
UniProt:Q7RTU4 BHA09
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:Q8IVS8 GLYCTK
1
GLYCTK [cytosol]
(R-HSA-6799244)
0.556
3
UniProt:Q9NYB9-2 ABI2
0.556
3
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