DVL is ubiquitinated by CUL3:KLHL12:RBX1

Stable Identifier
R-HSA-1504190
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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CUL3:KLHL12:RBX1 polyubiquitinates Dishevelled, targeting it for degradation by the proteasome (Angers et al, 2006).

Literature References
PubMed ID Title Journal Year
16547521 The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

Angers, S, Thorpe, CJ, Biechele, TL, Goldenberg, SJ, Zheng, N, Maccoss, MJ, Moon, RT

Nat Cell Biol 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of DVL:CUL3:KLHL12:RBX1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created