Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex
Stable Identifier
R-HSA-1504213
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of DVL (Homo sapiens)
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In response to WNT signaling, DVL is recruited to the CUL3:KLHL12:RBX1 ubiquitin ligase complex and is subsequently polyubiquitinated and degraded. The BTB domains of the adaptor protein KLHL12 bind constitutively to CUL3 while its Kelch domains mediate a WNT-dependent interaction with the C-terminus of DVL (Angers et al, 2006).
Literature References
PubMed ID
Title
Journal
Year
16547521
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation
Maccoss, MJ
,
Biechele, TL
,
Thorpe, CJ
,
Zheng, N
,
Angers, S
,
Goldenberg, SJ
,
Moon, RT
Nat Cell Biol
2006
Participants
Input
CUL3:KLHL12:RBX1 [cytosol]
(Homo sapiens)
DVL [cytosol]
(Homo sapiens)
Output
DVL:CUL3:KLHL12:RBX1 [cytosol]
(Homo sapiens)
Participates
as an event of
Degradation of DVL (Homo sapiens)
Orthologous Events
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Bos taurus)
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Danio rerio)
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Gallus gallus)
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Mus musculus)
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Rattus norvegicus)
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Sus scrofa)
Authored
Rothfels, K (2013-05-30)
Reviewed
Rajakulendran, N (2014-01-22)
van Amerongen, R (2014-02-15)
Kikuchi, A (2014-04-22)
Created
Rothfels, K (2011-08-24)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text