Reactome | Phosphorylation of SMAD2,3 by Activin:Activin Receptor

Phosphorylation of SMAD2,3 by Activin:Activin Receptor

Stable Identifier

R-HSA-1549526

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Phosphorylation of SMAD2,3 by Activin:Activin Receptor

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Activin receptors containing the type II receptors ACVR2A/B (ActRIIA, ActRIIB) and the type I receptors ACVR1B/C (ALK4, ALK7) signal through SMAD2 and SMAD3. The phosphorylated type I receptor (ACVR1B/C) phosphorylates SMAD2 or SMAD3. Homodimers or heterodimers of SMAD2 and SMAD3 bind the co-Smad SMAD4 and the ternary complex (SMAD2/3:SMAD2/3:SMAD4) enters the nucleus and activates expression of target genes.

Literature References

PubMed ID	Title	Journal	Year
16140969	Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells Burdette, JE, Jeruss, JS, Kurley, SJ, Lee, EJ, Woodruff, TK	Cancer Res	2005
17906079	MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4 Wang, Q, Huang, Z, Xue, H, Jin, C, Ju, XL, Han, JD, Chen, YG	Blood	2008
18951876	Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells Watanabe, R, Shen, ZP, Tsuda, K, Yamada, Y	Biochem. Biophys. Res. Commun.	2008
15087470	Receptor internalization-independent activation of Smad2 in activin signaling Zhou, Y, Scolavino, S, Funderburk, SF, Ficociello, LF, Zhang, X, Klibanski, A	Mol Endocrinol	2004
18166170	Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression Coutts, SM, Childs, AJ, Fulton, N, Collins, C, Bayne, RA, McNeilly, AS, Anderson, RA	Dev Biol	2008