Reactome | PRKCB [plasma membrane]

PRKCB [plasma membrane]

Stable Identifier

R-HSA-156467

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Protein kinase C, beta type , PKC-beta, PKC-B

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (z) signalling events (Homo sapiens)
      - G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC beta [plasma membrane] (Homo sapiens)
        
        PRKCB [plasma membrane] (Homo sapiens)
        
        p(S27)-G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC beta [plasma membrane] (Homo sapiens)
        
        PRKCB [plasma membrane] (Homo sapiens)
      - PKC binds active G alpha (z) (Homo sapiens)
        
        G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC beta [plasma membrane] (Homo sapiens)
        
        PRKCB [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC beta [plasma membrane] (Homo sapiens)
        
        PRKCB [plasma membrane] (Homo sapiens)
      - PKC phosphorylates G alpha (z) (Homo sapiens)
        
        G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC beta [plasma membrane] (Homo sapiens)
        
        PRKCB [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC beta [plasma membrane] (Homo sapiens)
        
        PRKCB [plasma membrane] (Homo sapiens)
        
        p(S27)-G-alpha(z):GTP:PKC [plasma membrane] (Homo sapiens)
        
        Protein kinase C conventional and novel isoforms [plasma membrane] (Homo sapiens)
        
        Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
        
        Activated PKC beta [plasma membrane] (Homo sapiens)
        
        PRKCB [plasma membrane] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - PCP/CE pathway (Homo sapiens)
      - WNT5A-dependent internalization of FZD4 (Homo sapiens)
        
        DVL2 is phosphorylated by PKC (Homo sapiens)
        
        Activated Protein kinase C (alpha, beta, gamma isoforms) [plasma membrane] (Homo sapiens)
        
        Activated PKC beta [plasma membrane] (Homo sapiens)
        
        PRKCB [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05771 PRKCB

Gene Names

PRKCB, PKCB, PRKCB1

Chain

initiator methionine:1, chain:2-671

Reference Genes

BioGPS Gene:5579 PRKCB

COSMIC (genes):PRKCB PRKCB

CTD Gene:5579 PRKCB

dbSNP Gene:5579 PRKCB

ENSEMBL:ENSG00000166501 PRKCB

HGNC:9395 PRKCB

KEGG:hsa:5579 PRKCB

Monarch:5579 PRKCB

NCBI Gene:5579 PRKCB

OMIM:176970 PRKCB

UCSC:P05771 PRKCB

Reference Transcript

Other Identifiers

11721922_at

11721923_a_at

11721924_s_at

1216_at

1217_g_at

1336_s_at

160029_at

16817044

207957_PM_s_at

207957_s_at

209685_PM_s_at

209685_s_at

227817_PM_at

227817_at

227824_PM_at

227824_at

228795_PM_at

228795_at

3653124

3653125

3653126

3653127

3653128

3653138

3653140

3653156

3653167

3653176

3653177

3653178

3653179

3653181

3653190

3653191

3653194

3653195

3653197

3653203

3653211

3653212

3653213

3653214

3653216

3653217

3653218

3653222

3653223

3653233

3653234

3653235

3653236

3653237

3653238

3653239

3653240

3653241

3653242

3653243

3653253

37301_at

54060_at

5579

62569_at

7994131

A_14_P119081

A_14_P138428

A_23_P206585

A_23_P88988

A_24_P935330

A_33_P3294533

GE59687

GE80408

GO:0000166

GO:0002250

GO:0002376

GO:0003682

GO:0003713

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0004698

GO:0005080

GO:0005246

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0006468

GO:0006816

GO:0006874

GO:0006915

GO:0007077

GO:0007165

GO:0007207

GO:0008091

GO:0008270

GO:0010827

GO:0010829

GO:0016020

GO:0016301

GO:0016740

GO:0030949

GO:0032024

GO:0035403

GO:0035556

GO:0042113

GO:0042393

GO:0042953

GO:0043123

GO:0044305

GO:0045766

GO:0045893

GO:0046627

GO:0046872

GO:0050681

GO:0050853

GO:0051049

GO:0061024

GO:0070062

GO:0070528

GO:0071322

GO:0098772

GO:0099171

GO:0099523

GO:0106310

GO:0140096

GO:2000300

HMNXSV003020489

Hs.6749.0.A1_3p_at

Hs.6749.1.A1_3p_at

Hs.6749.1.A2_3p_at

ILMN_1713603

ILMN_1716563

ILMN_1806908

M18255_cds2_s_at

PH_hs_0023926

PH_hs_0039907

TC16000260.hg

X06318_at

X07109_at

g189968_3p_at

g4506068_3p_a_at

Participates

as a component of

Activated PKC beta [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-T500,T642,S661-PRKCB [cytosol]

p-T500-PRKCB [cytosol]

PRKCB [cytosol]

p-T500,T642,S661-PRKCB [nucleoplasm]

Inferred To

PKC1 [plasma membrane] (Saccharomyces cerevisiae)

pck2 [plasma membrane] (Schizosaccharomyces pombe)

prkcb [plasma membrane] (Xenopus tropicalis)

PRKCB [plasma membrane] (Bos taurus)

PRKCB [plasma membrane] (Canis familiaris)

PRKCB [plasma membrane] (Dictyostelium discoideum)

PRKCB [plasma membrane] (Gallus gallus)

pkc-2 [plasma membrane] (Caenorhabditis elegans)

Pkc53E [plasma membrane] (Drosophila melanogaster)

inaC [plasma membrane] (Drosophila melanogaster)

Prkcb [plasma membrane] (Mus musculus)

Prkcb [plasma membrane] (Rattus norvegicus)

pkbA [plasma membrane] (Dictyostelium discoideum)

pck1 [plasma membrane] (Schizosaccharomyces pombe)

Homologues of PRKCB [plasma membrane] (Dictyostelium discoideum)

Homologues of PRKCB [plasma membrane] (Drosophila melanogaster)

Homologues of PRKCB [plasma membrane] (Schizosaccharomyces pombe)

prkcbb [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_997700.1, NP_002729.2

Guide to Pharmacology - Targets

1483

OpenTargets

ENSG00000166501

ENSEMBL

ENST00000643927, ENST00000321728, ENSP00000318315, ENSP00000496129, ENSG00000166501

ZINC - Substances

KPCB_HUMAN

ZINC - Biogenic

KPCB_HUMAN

ZINC target

P05771

PRO

P05771

PDB

8SG2, 2I0E

ZINC - Investigational

KPCB_HUMAN

IntEnz

2.7.11.13

HPA

ENSG00000166501-PRKCB

GeneCards

PRKCB

Pharos - Targets

P05771

ZINC - Predictions - Purchasable

KPCB_HUMAN

HMDB Protein

HMDBP01372

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NEM2 SHCBP			0.564	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.547	2
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) p-T497-PRKCA [cytosol] (R-HSA-5218731) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) PRKCA [plasma membrane] (R-HSA-156469) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.527	3
UniProt:Q05655 PRKCD	12	PRKCD [cytosol] (R-HSA-58200) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD(330-676) [cytosol] (R-HSA-212551) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507-PRKCD [cytosol] (R-HSA-5218746) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-676) [nucleoplasm] (R-HSA-450606)	0.527	2
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:Q9NRW3 APOBEC3C	1	APOBEC3C [nucleoplasm] (R-HSA-8874997)	0.483	2