Reactome | NXF1 [cytosol]

NXF1 [cytosol]

Stable Identifier

R-HSA-156481

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TAP, Nuclear RNA export factor 1, Tip associating protein, Tip-associated protein, mRNA export factor TAP

Locations in the PathwayBrowser for interactor UniProt:P84103 SRSF3

Expand all

External Reference Information

External Reference

UniProt:Q9UBU9 NXF1

Gene Names

NXF1, TAP

Chain

initiator methionine:, chain:2-619

Reference Genes

BioGPS Gene:10482 NXF1

COSMIC (genes):NXF1 NXF1

CTD Gene:10482 NXF1

dbSNP Gene:10482 NXF1

ENSEMBL:ENSG00000162231 NXF1

HGNC:8071 NXF1

KEGG:hsa:10482 NXF1

Monarch:10482 NXF1

NCBI Gene:10482 NXF1

OMIM:602647 NXF1

UCSC:Q9UBU9 NXF1

Reference Transcript

Other Identifiers

10482

11742713_at

11751750_a_at

11756543_a_at

16739552

208922_PM_s_at

208922_s_at

213818_PM_x_at

213818_x_at

220934_PM_s_at

220934_s_at

3376145

3376146

3376147

3376148

3376149

3376150

3376153

3376154

3376156

3376157

3376158

3376159

3376160

3376161

3376162

3376163

3376164

3376165

3376166

3376167

3376168

3376169

3376170

3376171

3376172

3376173

3376174

3376175

3376176

3376177

3376178

3376179

3376180

3376181

3376182

3376183

3376184

3376185

3376186

3376187

3376188

3376189

3376191

3376192

35302_at

44091_at

7948836

7948839

88144_at

A_23_P13359

A_23_P1956

GE55229

GE58079

GE82793

GE86260

GO:0000346

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005737

GO:0005829

GO:0006405

GO:0006406

GO:0006913

GO:0010494

GO:0015031

GO:0016607

GO:0016973

GO:0042272

GO:0042405

GO:0043226

GO:0051028

HMNXSV003022217

HMNXSV003026572

HMNXSV003045146

HMNXSV003052152

Hs.146428.3.A1_3p_a_at

ILMN_1705783

ILMN_1722674

ILMN_2263144

ILMN_2358652

M76729_at

PH_hs_0016105

PH_hs_0036151

TC11001880.hg

U80073_at

g13129079_3p_a_at

g13436184_3p_s_at

Participates

as an output of

as a component of

as a member of

NXF1,2 [cytosol] (Homo sapiens)

Other forms of this molecule

NXF1 [nucleoplasm]

Inferred To

MEX67 [cytosol] (Saccharomyces cerevisiae)

mex67 [cytosol] (Schizosaccharomyces pombe)

Nxf1 [cytosol] (Mus musculus)

Nxf1 [cytosol] (Rattus norvegicus)

nxf-1 [cytosol] (Caenorhabditis elegans)

NXF1 [cytosol] (Bos taurus)

NXF1 [cytosol] (Canis familiaris)

NXF1 [cytosol] (Gallus gallus)

NXF1 [cytosol] (Sus scrofa)

sbr [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001074960.1, NP_006353.2

OpenTargets

ENSG00000162231

ENSEMBL

ENSP00000436679, ENSP00000453885, ENST00000532297, ENSP00000294172, ENST00000531709, ENST00000294172

HPA

ENSG00000162231-NXF1

PRO

Q9UBU9

Pharos - Targets

Q9UBU9

GlyGen

Q9UBU9

PDB

3RW7, 1OAI, 1JN5, 2Z5M, 1FO1, 6E5U, 1KOH, 1JKG, 3RW6, 1KOO, 1GO5, 1FT8, 2Z5K, 4WYK

Interactors (94)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UKK6 NXT1	2	NXT1 [cytosol] (R-HSA-8849122) NXT1 [nucleoplasm] (R-HSA-8849151)	0.882	8
UniProt:P37198 NUP62	2	NUP62 [nuclear envelope] (R-HSA-157713) NUP62 [cytosol] (R-HSA-9634226)	0.882	12
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.809	6
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.781	7
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.764	8
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.759	4
UniProt:P35658 NUP214	2	NUP214 [nucleoplasm] (R-HSA-451222) NUP214 [cytosol] (R-HSA-157691)	0.759	4
UniProt:Q96CG3 TIFA	2	TIFA [cytosol] (R-HSA-451582) p-T9-TIFA [cytosol] (R-HSA-9645512)	0.718	6
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.667	4
UniProt:O95751 LDOC1			0.666	4
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.656	4
UniProt:Q9Y3Y2 CHTOP	1	CHTOP [nucleoplasm] (R-HSA-8849147)	0.653	9
UniProt:Q9NPJ8 NXT2			0.643	4
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.623	4
UniProt:P10238 ICP27			0.619	4
UniProt:P22575 TIP			0.616	6
UniProt:P52948 NUP98			0.609	2
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.599	5
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:Q9H079 KTBL1			0.556	5
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.556	3
UniProt:Q9NR46 SHLB2			0.556	3
UniProt:Q5SWW7 CJ055			0.556	3
UniProt:P49761 CLK3			0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:Q9BYV9 BACH2			0.556	3
UniProt:Q96MP8-2 KCTD7			0.556	3
UniProt:Q9BZL4 PP12C			0.556	3
UniProt:A0A1B0GWI1 A0A1B0GWI1			0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q8N6V9 TEX9			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q8WWY6 MB3L1			0.556	3
UniProt:Q9P2M4 TBC1D14	1	TBC1D14 [recycling endosome] (R-HSA-8854764)	0.556	3
UniProt:Q96M83-3 Q96M833			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:Q86WP2 GPBP1			0.556	3
UniProt:Q8NCU1 CC197			0.556	3
UniProt:Q13867 BLMH	1	BLMH [cytosol] (R-HSA-983095)	0.556	3
UniProt:Q9ULR0-1 Q9ULR01			0.556	3
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.556	3
UniProt:Q9UK41-2 VPS28			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:P79522 PRR3			0.556	3
UniProt:B2RXH4 BTBDI			0.556	3
UniProt:Q6P1L6 ZNF343	1	ZNF343 [nucleoplasm] (R-HSA-1247536)	0.556	3
UniProt:P41219 PERI			0.556	3
UniProt:Q9H0A9-2 SPATC1L			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q96DF8 ESS2			0.556	3
UniProt:Q9H7T9 AUNIP			0.556	3
UniProt:Q6NTE8 MRNIP			0.556	3
UniProt:Q8TDR4 TCP1L			0.556	3
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [extracellular region] (R-HSA-8863001) GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960)	0.556	3
UniProt:Q86WS4 RDIC1			0.556	3
UniProt:Q6ZUT1 NKAP1			0.556	3
UniProt:Q8WWB5 PIHD2			0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q8IZU3 SYCP3	1	SYCP3 [nucleoplasm] (R-HSA-912329)	0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:Q8N8U2 CDYL2			0.556	3
UniProt:P15622-3 ZNF250			0.556	3
UniProt:Q5T5B0 LCE3E	1	LCE3E [cytosol] (R-HSA-6814280)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q8ND83 SLAI1			0.556	3
UniProt:P49760 CLK2			0.556	3
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.556	3
UniProt:Q9C0B1-2 Q9C0B12			0.556	3
UniProt:Q13555-5 CAMK2G			0.556	3
UniProt:Q96P16-3 RPRD1A			0.556	3
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.556	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:Q9NQY0 BIN3			0.556	3
UniProt:P78406 RAE1	1	RAE1 [nuclear envelope] (R-HSA-157718)	0.544	2
UniProt:Q9BUJ2 HNRNPUL1	1	HNRNPUL1 [nucleoplasm] (R-HSA-72106)	0.544	2
UniProt:Q92973 TNPO1	2	TNPO1 [cytosol] (R-HSA-180743) TNPO1 [cilium] (R-HSA-5624896)	0.544	2
UniProt:P84103 SRSF3	1	SRSF3 [nucleoplasm] (R-HSA-72035)	0.544	4
UniProt:Q9Y2Z4 YARS2	1	YARS2 [mitochondrial matrix] (R-HSA-379634)	0.527	2
UniProt:P46060 RANGAP1	3	RANGAP1 [cytosol] (R-HSA-376255) RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416)	0.527	2
UniProt:Q9H1J1 UPF3A	1	UPF3A [cytosol] (R-HSA-927801)	0.527	2
UniProt:Q9H000 MKRN2			0.527	2
UniProt:Q99666 RGPD5			0.527	2
UniProt:O15234 CASC3	2	CASC3 [nucleoplasm] (R-HSA-8849148) CASC3 [cytosol] (R-HSA-927807)	0.527	2
UniProt:O15354 GPR37	1	GPR37 [plasma membrane] (R-HSA-5333623)	0.527	2
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.527	2
UniProt:Q9BZI7 UPF3B	2	UPF3B [cytosol] (R-HSA-159258) UPF3B [nucleoplasm] (R-HSA-156776)	0.527	2
UniProt:P49792 RANBP2	6	RANBP2 [cytosol] (R-HSA-157703) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [nuclear envelope] (R-HSA-2993756) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720)	0.527	2
UniProt:Q9NXV2 KCTD5			0.488	2

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