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p-S216-CDC25C [nucleoplasm]
Stable Identifier
R-HSA-156496
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
phosph-Cdc25C (Ser 216), M-phase inducer phosphatase 3 , Dual specificity phosphatase Cdc25C
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Homo sapiens)
p-S216-CDC25C [nucleoplasm] (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Homo sapiens)
Phosphorylation of Cdc25C at Ser216 by CHEK2 (Homo sapiens)
p-S216-CDC25C [nucleoplasm] (Homo sapiens)
p-S216-CDC25C translocates to the cytosol (Homo sapiens)
p-S216-CDC25C [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30307 CDC25C
Gene Names
CDC25C
Chain
initiator methionine:1, chain:2-473
Reference Genes
BioGPS Gene:995 CDC25C
COSMIC (genes):CDC25C CDC25C
CTD Gene:995 CDC25C
dbSNP Gene:995 CDC25C
ENSEMBL:ENSG00000158402 CDC25C
ENSEMBL:ENSG00000158402.21 CDC25C
HGNC:1727 CDC25C
KEGG Gene (Homo sapiens):995 CDC25C
Monarch:995 CDC25C
NCBI Gene:995 CDC25C
OMIM:157680 CDC25C
UCSC:P30307 CDC25C
Reference Transcript
RefSeq:NM_022809.3 CDC25C
RefSeq:NM_001287582.1 CDC25C
RefSeq:XM_011543762.1 CDC25C
RefSeq:NM_001318098.1 CDC25C
RefSeq:NM_001790.4 CDC25C
Other Identifiers
11720835_a_at
11748104_a_at
1584_at
17000439
205167_PM_s_at
205167_s_at
217010_PM_s_at
217010_s_at
2877379
2877380
2877381
2877382
2877384
2877387
2877388
2877390
2877392
2877393
2877396
2877397
2877399
2877400
2877402
2877403
2877404
2877406
2877407
2877410
2877411
8114425
995
A_23_P70249
GE57938
GO:0000079
GO:0000086
GO:0000278
GO:0003824
GO:0004721
GO:0004725
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005758
GO:0005829
GO:0006470
GO:0007049
GO:0007088
GO:0007283
GO:0008283
GO:0010971
GO:0016787
GO:0019901
GO:0022414
GO:0036211
GO:0043226
GO:0048471
GO:0050699
GO:0051301
GO:0110032
GO:0140014
GO:0140096
GO:1902751
HMNXSV003054256
Hs.656.2.S1_3p_a_at
ILMN_1725260
ILMN_2294431
ILMN_2407619
M34065_at
TC05001829.hg
TC05003257.hg
Z29077_xpt1_at
g12408659_3p_a_at
Participates
as an output of
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Homo sapiens)
Phosphorylation of Cdc25C at Ser216 by CHEK2 (Homo sapiens)
as an input of
p-S216-CDC25C translocates to the cytosol (Homo sapiens)
Other forms of this molecule
p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]
p-S191-CDC25C [nucleoplasm]
p-S216-CDC25C [cytosol]
CDC25C [nucleoplasm]
p-S198-CDC25C [cytosol]
CDC25C [cytosol]
p-S198-CDC25C [nucleoplasm]
Inferred To
phospho-cdc-25.2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-Cdc25c [nucleoplasm]
(Mus musculus)
phospho-Cdc25c [nucleoplasm]
(Rattus norvegicus)
phospho-cdc25 [nucleoplasm]
(Danio rerio)
phospho-cdc25 [nucleoplasm]
(Dictyostelium discoideum)
phospho-cdc25 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-cdc25b [nucleoplasm]
(Xenopus tropicalis)
phospho-cdc-25.3 [nucleoplasm]
(Caenorhabditis elegans)
phospho-cdc25a [nucleoplasm]
(Xenopus tropicalis)
phospho-stg [nucleoplasm]
(Drosophila melanogaster)
phospho-cdc-25.1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-CDC25C [nucleoplasm]
(Bos taurus)
phospho-CDC25C [nucleoplasm]
(Sus scrofa)
phospho-cdc-25.4 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S216-CDC25C [nucleoplasm]
(Canis familiaris)
phospho-p-S216-CDC25C [nucleoplasm]
(Gallus gallus)
phospho-MIH1 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-twe [nucleoplasm]
(Drosophila melanogaster)
phospho-XB5832479 [nucleoplasm]
(Xenopus tropicalis)
Homologues of p-S216-CDC25C [nucleoplasm]
(Caenorhabditis elegans)
Homologues of p-S216-CDC25C [nucleoplasm]
(Drosophila melanogaster)
Homologues of p-S216-CDC25C [nucleoplasm]
(Sus scrofa)
Homologues of p-S216-CDC25C [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 216
Coordinate
216
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001274511.1
,
NP_073720.1
,
XP_011542064.1
,
NP_001781.2
,
NP_001305027.1
OpenTargets
ENSG00000158402
GeneCards
P30307
HPA
ENSG00000158402-CDC25C
ZINC - Substances
MPIP3_HUMAN
ZINC target
P30307
Ensembl
ENST00000514555
,
ENST00000415130
,
ENSP00000425470
,
ENSG00000158402
,
ENST00000323760
,
ENSP00000321656
,
ENST00000513970
,
ENSP00000392631
,
ENSP00000424795
PRO
P30307
Pharos - Targets
P30307
ZINC - Predictions - Purchasable
MPIP3_HUMAN
HMDB Protein
HMDBP08921
PDB
2OJX
,
3OP3
,
3BZI
,
5M36
,
5M35
,
5M37
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.858
8
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.744
5
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.643
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.643
3
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.623
3
UniProt:O14757 CHEK1
3
CHEK1 [cytosol]
(R-HSA-205285)
CHEK1 [nucleoplasm]
(R-HSA-113826)
p-S317,S345-CHEK1 [nucleoplasm]
(R-HSA-113838)
0.623
2
UniProt:Q14738 PPP2R5D
2
PPP2R5D [nucleoplasm]
(R-HSA-3008956)
PPP2R5D [cytosol]
(R-HSA-3008950)
0.589
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.564
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
2
UniProt:Q9UMX1 SUFU
3
SUFU [ciliary base]
(R-HSA-5610424)
SUFU [cytosol]
(R-HSA-445455)
SUFU [ciliary tip]
(R-HSA-5610426)
0.527
2
UniProt:Q9Y250 LZTS1
0.499
2
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