CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO

Stable Identifier
R-HSA-156526
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Aflatoxin B1 oxidized to Aflatoxin-8,9-oxide
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Aflatoxin B1 (AFB1) requires microsomal oxidation to produce epoxides which cause the toxic and carcinogenic effects. In humans, cytochrome P450 enzymes produce epoxide stereoisomers of AFB1, the most potent being aflatoxin exo-8,9-oxide (AFXBO). This conversion is carried out by at least four P450s; 1A2, 3A4, 3A5 and 2A13. CYP3A4 mainly produces the exo form whereas CYP1A2 produces a racemic mixture of exo and endo forms (Gallagher et al. 1996, He et al. 2006).

Literature References
PubMed ID Title Journal Year
16385575 Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract

He, XY, Tang, L, Wang, SL, Cai, QS, Wang, JS, Hong, JY

Int. J. Cancer 2006
8975785 The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4

Gallagher, EP, Kunze, KL, Stapleton, PL, Eaton, DL

Toxicol. Appl. Pharmacol. 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP1A2,3A4,3A5,2A13 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created