Cytosolic sulfonation of small molecules

Stable Identifier
R-HSA-156584
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Two groups of sulfotransferease (SULT) enzymes catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate (PAPS) to a hydroxyl group on an acceptor molecule, yielding a sulfonated acceptor and 3-phosphoadenosine 5-phosphate (PAP). One is localized to the Golgi apparatus and mediates the sulfonation of proteoglycans. The second, annotated here, is cytosolic and mediates the sulfonation of a diverse array of small molecules, increasing their solubilities in water and modifying their physiological functions. There are probably thirteen or more human cytosolic SULT enzymes; eleven of these have been purified and characterized enzymatically, and are annotated here (Blanchard et al. 2004; Gamage et al. 2005). These enzymes appear to be active as dimers. Their substrate specificities are typically broad, and not related in an obvious way to their structures; indeed, apparently orthologous human and rodent SULT enzymes can have different substrate specificities (Glatt 2000), and none has been exhaustively characterized. The substrates listed in the table and annotated here are a sample of the known ones, chosen to indicate the range of activity of these enzymes and to capture some of their known physiologically important targets. Absence of a small molecule - enzyme pair from the table, however, may only mean that it has not yet been studied.

Literature References
PubMed ID Title Journal Year
  Casarett and Doull's Toxicology 5th Edn

Parkinson, A

  1995
9034160 Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes

Weinshilboum, RM, Otterness, DM, Aksoy, IA, Wood, TC, Her, C, Raftogianis, RB

FASEB J 1997
12372849 Sulfonation and molecular action

Strott, CA

Endocr Rev 2002
10503886 Sulfotransferase catalyzing sulfation of heterocyclic amines

Yamazoe, Y, Nagata, K, Yoshinari, K, Fujita, K, Shiraga, T, Iwasaki, K

Cancer Lett 1999
Participants
Participant Of
Event Information
Orthologous Events
Authored
Created