Reactome | RBM8A [nucleoplasm]

RBM8A [nucleoplasm]

Stable Identifier

R-HSA-156659

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RBM8A/Y14

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
  - mRNA 3'-end processing (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Spliced mRNP [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
    - mRNA polyadenylation (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
        
        Spliced mRNP [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
        
        pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
        
        pre-EJC complex [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Formation of Exon Junction Complex (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
        
        pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
        
        pre-EJC complex [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5S9 RBM8A

Gene Names

RBM8A, RBM8, HSPC114, MDS014

Chain

initiator methionine:1, chain:2-174

Reference Genes

BioGPS Gene:9939 RBM8A

COSMIC (genes):RBM8A RBM8A

CTD Gene:9939 RBM8A

dbSNP Gene:9939 RBM8A

ENSEMBL:ENSG00000265241 RBM8A

HGNC:9905 RBM8A

KEGG Gene (Homo sapiens):9939 RBM8A

Monarch:9939 RBM8A

NCBI Gene:9939 RBM8A

OMIM:605313 RBM8A

UCSC:Q9Y5S9 RBM8A

Reference Transcript

RefSeq:NM_005105.4 RBM8A

Other Identifiers

0000610398

11717422_s_at

11717423_s_at

11758777_x_at

11763501_s_at

16669830

16669840

213852_at

214113_3p_s_at

214113_s_at

217856_at

217857_s_at

222443_s_at

2355705

2356182

2356183

2356188

2356191

2356193

2356195

2356197

2356198

2356199

2356200

2356201

2356202

2356203

2356204

2356206

2356207

2356208

2356209

2356210

3538612

3538613

3538614

3538615

3538616

3538617

3538618

40819_at

40820_at

64886_at

7904751

8180286

9939

A_14_P139097

A_23_P104116

A_24_P79955

A_32_P62571

GE58355

GE61533

GO:0000184

GO:0000381

GO:0000398

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0005829

GO:0006396

GO:0006397

GO:0006405

GO:0006406

GO:0006412

GO:0006417

GO:0006810

GO:0006913

GO:0008150

GO:0008380

GO:0009056

GO:0009058

GO:0015031

GO:0016607

GO:0030425

GO:0031124

GO:0032991

GO:0034641

GO:0034655

GO:0035145

GO:0043025

GO:0043226

GO:0051028

GO:0071006

GO:0071013

Hs.65648.0.S3_3p_at

Hs.65648.1.A1_3p_s_at

Hs.65648.2.A1_3p_at

ILMN_1781870

PH_hs_0030984

TC01001093.hg

g10197629_3p_s_at

g4826971_3p_s_at

Participant Of

hasComponent

Magoh-Y14 complex [nucleoplasm]

Other forms of this molecule

RBM8A [cytosol]

Inferred To

RBM8A [nucleoplasm] (Canis familiaris)

RBM8A [nucleoplasm] (Dictyostelium discoideum)

RBM8A [nucleoplasm] (Gallus gallus)

RBM8A [nucleoplasm] (Schizosaccharomyces pombe)

RBM8A [nucleoplasm] (Sus scrofa)

rbm8a [nucleoplasm] (Danio rerio)

rbm8a [nucleoplasm] (Xenopus tropicalis)

rnp-4 [nucleoplasm] (Caenorhabditis elegans)

tsu [nucleoplasm] (Drosophila melanogaster)

Rbm8a [nucleoplasm] (Mus musculus)

Rbm8a [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_005096.1

Target Pathogen

5b354852be737e166372e9a8

OpenTargets

ENSG00000265241

GeneCards

Q9Y5S9

HPA

ENSG00000265241-RBM8A

Ensembl

ENST00000369307, ENSP00000488265, ENSG00000265241, ENSP00000358313, ENSP00000463058, ENST00000632555, ENST00000583313

PRO

Q9Y5S9

Orphanet

21071

PDB

2HYI, 6QDV, 5YZG, 2J0S, 1P27, 3EX7, 2XB2, 6ICZ, 2J0Q, 5XJC

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.921	21
UniProt:Q9BZI7 UPF3B	2	UPF3B [cytosol] (R-HSA-159258) UPF3B [nucleoplasm] (R-HSA-156776)	0.914	10
UniProt:O15234 CASC3	2	CASC3 [cytosol] (R-HSA-927807) CASC3 [nucleoplasm] (R-HSA-8849148)	0.813	5
UniProt:Q92900 UPF1	2	p-4S-UPF1 [cytosol] (R-HSA-927856) UPF1 [cytosol] (R-HSA-927734)	0.643	3
UniProt:P52298 NCBP2	2	NCBP2 [cytosol] (R-HSA-162458) NCBP2 [nucleoplasm] (R-HSA-51463)	0.527	2
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.512	3

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