Reactome | Formation of Exon Junction Complex

Formation of Exon Junction Complex

Stable Identifier

R-HSA-156661

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

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Summation

At the beginning of this reaction, 1 molecule of 'Magoh-Y14 complex', and 1 molecule of 'Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex' are present. At the end of this reaction, 1 molecule of 'Exon Junction Complex' is present.

This reaction takes place in the 'nucleoplasm'.

Literature References

PubMed ID	Title	Journal	Year
14625303	A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex Kataoka, N, Dreyfuss, G	J Biol Chem	2004
23345524	Rearrangements within human spliceosomes captured after exon ligation Ilagan, JO, Chalkley, RJ, Burlingame, AL, Jurica, MS	RNA	2013
11118221	The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions Le Hir, H, Izaurralde, E, Maquat, LE, Moore, MJ	EMBO J	2000
12414731	5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly Reichert, VL, Le, Hir H, Jurica, MS, Moore, MJ	Genes Dev	2002
22959432	CWC22 connects pre-mRNA splicing and exon junction complex assembly Steckelberg, AL, Boehm, V, Gromadzka, AM, Gehring, NH	Cell Rep	2012
11532962	The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay Le Hir, H, Gatfield, D, Izaurralde, E, Moore, MJ	EMBO J	2001