Reactome: A Curated Pathway Database

Formation of Exon Junction Complex

Stable Identifier
R-HSA-156661
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Summation

At the beginning of this reaction, 1 molecule of 'Magoh-Y14 complex', and 1 molecule of 'Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex' are present. At the end of this reaction, 1 molecule of 'Exon Junction Complex' is present.

This reaction takes place in the 'nucleoplasm'.

Literature References
PubMed ID Title Journal Year
14625303 A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex J Biol Chem 2004
23345524 Rearrangements within human spliceosomes captured after exon ligation RNA 2013
11118221 The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions EMBO J 2000
12414731 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly Genes Dev 2002
22959432 CWC22 connects pre-mRNA splicing and exon junction complex assembly Cell Rep 2012
11532962 The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay EMBO J 2001
Participants
input
output
Participant Of
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Orthologous Events
 
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