Formation of Exon Junction Complex

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

At the beginning of this reaction, 1 molecule of 'Magoh-Y14 complex', and 1 molecule of 'Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex' are present. At the end of this reaction, 1 molecule of 'Exon Junction Complex' is present.

This reaction takes place in the 'nucleoplasm'.

Literature References
PubMed ID Title Journal Year
14625303 A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex

Kataoka, N, Dreyfuss, G

J Biol Chem 2004
23345524 Rearrangements within human spliceosomes captured after exon ligation

Ilagan, JO, Chalkley, RJ, Burlingame, AL, Jurica, MS

RNA 2013
11118221 The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

Le Hir, H, Izaurralde, E, Maquat, LE, Moore, MJ

EMBO J 2000
12414731 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly

Reichert, VL, Le, Hir H, Jurica, MS, Moore, MJ

Genes Dev 2002
22959432 CWC22 connects pre-mRNA splicing and exon junction complex assembly

Steckelberg, AL, Boehm, V, Gromadzka, AM, Gehring, NH

Cell Rep 2012
11532962 The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

Le Hir, H, Gatfield, D, Izaurralde, E, Moore, MJ

EMBO J 2001
Participant Of
Orthologous Events