Reactome | Polo-like kinase mediated events

Polo-like kinase mediated events

Stable Identifier

R-HSA-156711

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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At mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A (Watanabe et al. 2004). Plk1 also phosphorylates and inhibits Myt1 activity (Sagata 2005). Cyclin B1-bound Cdc2, which is the target of Cdc25C, Wee1A, and Myt1, functions in a feedback loop and phosphorylates the latter components (Cdc25C, Wee1A, Myt1). The Cdc2- dependent phosphorylation provides docking sites for the polo-box domain of Plk1, thus promoting the Plk1-dependent regulation of these components and, as a result, activation of Cdc2-Cyclin B1.

PLK1 phosphorylates and activates the transcription factor FOXM1 which stimulates the expression of a number of genes needed for G2/M transition, including PLK1, thereby creating a positive feedback loop (Laoukili et al. 2005, Fu et al. 2008, Sadasivam et al. 2012, Chen et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
19160488	Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression Fu, Z, van Deursen, JM, Li, H, Chen, J, Huang, J, Tindall, DJ, Malureanu, L, Wang, W	Nat. Cell Biol.	2008
23109430	The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism Fischer, M, Chen, X, Stutchbury, B, Sharrocks, AD, Engeland, K, Han, N, Müller, GA, Quaas, M	Mol. Cell. Biol.	2013
15070733	M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP Nishihara, Y, Taniguchi, M, Arai, H, Watanabe, N, Osada, H, Hunter, T, Watanabe, N	Proc Natl Acad Sci U S A	2004
15692562	The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs Sagata, N	EMBO J	2005
22391450	The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression Duan, S, Sadasivam, S, DeCaprio, JA	Genes Dev.	2012
15654331	FoxM1 is required for execution of the mitotic programme and chromosome stability Kooistra, MR, Brás, A, Medema, RH, Clevers, HC, Kauw, J, Laoukili, J, Morrison, A, Kerkhoven, RM	Nat. Cell Biol.	2005