Reactome | NUDC [nucleoplasm]

NUDC [nucleoplasm]

Stable Identifier

R-HSA-156716

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:P25685 DNAJB1

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External Reference Information

External Reference

UniProt:Q9Y266 NUDC

Gene Names

NUDC

Chain

chain:1-331

Reference Genes

BioGPS Gene:10726 NUDC

COSMIC (genes):NUDC NUDC

CTD Gene:10726 NUDC

dbSNP Gene:10726 NUDC

ENSEMBL:ENSG00000090273 NUDC

HGNC:8045 NUDC

KEGG:hsa:10726 NUDC

Monarch:10726 NUDC

NCBI Gene:10726 NUDC

OMIM:610325 NUDC

UCSC:Q9Y266 NUDC

Reference Transcript

RefSeq:NM_006600.3 NUDC

Other Identifiers

10726

11716166_x_at

16661323

201173_PM_x_at

201173_x_at

210574_PM_s_at

210574_s_at

2326800

2326802

2326803

2326805

2326806

2326807

2326808

2326812

2326813

2326814

2326815

2326816

2326817

2326818

2326819

2326820

2326821

2326822

2326823

2326824

2326827

2326828

2326829

2510739

2510740

2510743

2517704

2517706

2517709

2517710

2517713

35836_at

7899273

A_23_P74653

GE79197

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0006457

GO:0007010

GO:0007052

GO:0007080

GO:0007097

GO:0016020

GO:0030496

GO:0043226

GO:0043434

GO:0045296

GO:0051082

GO:0051301

GO:0072686

HMNXSV003014386

ILMN_2097546

PH_hs_0029543

TC01000355.hg

g12005492_3p_s_at

Participates

as an input of

PLK1 phosphorylates NUDC (Homo sapiens)

Other forms of this molecule

NUDC [cytosol]

p-S274,S326-NUDC [cytosol]

p-S274,S326-NUDC [spindle]

Inferred To

NUDC [nucleoplasm] (Bos taurus)

NUDC [nucleoplasm] (Canis familiaris)

NUDC [nucleoplasm] (Gallus gallus)

NUDC [nucleoplasm] (Plasmodium falciparum)

NUDC [nucleoplasm] (Sus scrofa)

nud-1 [nucleoplasm] (Caenorhabditis elegans)

nudc [nucleoplasm] (Danio rerio)

nudc [nucleoplasm] (Dictyostelium discoideum)

nudc [nucleoplasm] (Schizosaccharomyces pombe)

nudc [nucleoplasm] (Xenopus tropicalis)

Nudc [nucleoplasm] (Mus musculus)

Nudc [nucleoplasm] (Rattus norvegicus)

nudC [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_006591.1

OpenTargets

ENSG00000090273

ENSEMBL

ENSP00000319664, ENST00000321265

HPA

ENSG00000090273-NUDC

PRO

Q9Y266

Pharos - Targets

Q9Y266

GlyGen

Q9Y266

PDB

7NDX, 3QOR

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TC44 POC1B			0.731	5
UniProt:Q8WVS4 DYNC2I1	2	WDR60 [ciliary tip] (R-HSA-5625409) WDR60 [cilium] (R-HSA-5624903)	0.657	4
UniProt:Q8NBT0 POC1A			0.65	3
UniProt:P25685 DNAJB1	3	DNAJB1 [nucleoplasm] (R-HSA-5082366) DNAJB1 [cytosol] (R-HSA-3299666) p-S149,S151,S171 DNAJB1 [cytosol] (R-HSA-5690241)	0.638	3
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.623	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	8
UniProt:Q9P2S5 WRP73			0.564	2
UniProt:O00423 EMAL1			0.564	2
UniProt:Q96P53 WDFY2			0.564	2
UniProt:P02489 CRYAA			0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:O14908-2 GIPC1			0.556	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.527	3
UniProt:Q92918 M4K1			0.527	3
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.527	2
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.527	3
UniProt:Q9UG01 IFT172	2	IFT172 [ciliary tip] (R-HSA-5625353) IFT172 [cilium] (R-HSA-5610383)	0.508	2
UniProt:Q9P2H3 IFT80	2	IFT80 [ciliary tip] (R-HSA-5625367) IFT80 [cilium] (R-HSA-5617613)	0.508	3
UniProt:P32780 GTF2H1	1	GTF2H1 [nucleoplasm] (R-HSA-65912)	0.508	2
UniProt:Q9UDY4 DNJB4			0.508	2
UniProt:Q9UKT8 FBXW2	1	FBXW2 [cytosol] (R-HSA-391300)	0.499	2
UniProt:Q9Y4P8 WIPI2	1	WIPI2 [cytosol] (R-HSA-5678305)	0.483	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11
UniProt:P03366 POL			0.462	2

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