Reactome | PLK1 [nucleoplasm]

PLK1 [nucleoplasm]

Stable Identifier

R-HSA-156720

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P53350 PLK1

Gene Names

PLK1, PLK

Chain

initiator methionine:, chain:2-603

Reference Genes

BioGPS Gene:5347 PLK1

COSMIC (genes):PLK1 PLK1

CTD Gene:5347 PLK1

dbSNP Gene:5347 PLK1

ENSEMBL:ENSG00000166851 PLK1

ENSEMBL_homo_sapiens_GENE:ENSG00000166851.15 PLK1

HGNC:9077 PLK1

KEGG Gene (Homo sapiens):5347 PLK1

Monarch:5347 PLK1

NCBI Gene:5347 PLK1

OMIM:602098 PLK1

UCSC:P53350 PLK1

Reference Transcript

RefSeq:NM_005030.5 PLK1

Other Identifiers

11716726_a_at

11716727_x_at

11750302_a_at

16817017

202240_PM_at

202240_at

3137730

3653073

3653074

3653075

3653076

3653079

3653080

3653081

3653083

3653085

3653086

3653088

3653090

3653092

3653093

37228_at

5347

7994109

A_14_P113539

A_24_P313504

A_33_P3298387

GO:0000070

GO:0000086

GO:0000122

GO:0000132

GO:0000166

GO:0000228

GO:0000278

GO:0000281

GO:0000287

GO:0000775

GO:0000776

GO:0000779

GO:0000785

GO:0000795

GO:0000910

GO:0000922

GO:0000940

GO:0001578

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005876

GO:0006281

GO:0006302

GO:0006351

GO:0006355

GO:0006468

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007062

GO:0007076

GO:0007077

GO:0007091

GO:0007094

GO:0007095

GO:0007098

GO:0007163

GO:0007346

GO:0008017

GO:0008092

GO:0010800

GO:0010997

GO:0012501

GO:0015630

GO:0016301

GO:0016310

GO:0016321

GO:0016567

GO:0016740

GO:0018105

GO:0019901

GO:0022414

GO:0023052

GO:0030071

GO:0030163

GO:0030496

GO:0031648

GO:0032436

GO:0032465

GO:0033365

GO:0034451

GO:0036211

GO:0042802

GO:0043066

GO:0043226

GO:0043393

GO:0045143

GO:0045184

GO:0045736

GO:0045862

GO:0048313

GO:0051081

GO:0051233

GO:0051301

GO:0051443

GO:0051726

GO:0061024

GO:0070194

GO:0071168

GO:0090435

GO:0097431

GO:0097681

GO:0106310

GO:0140013

GO:0140014

GO:0140096

GO:1900182

GO:1901673

GO:1901990

GO:1904668

GO:1904776

GO:1905784

HMNXSV003006606

ILMN_1736176

PH_hs_0032688

TC16000258.hg

U01038_at

g4826915_3p_at

Participates

as an output of

Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)

Other forms of this molecule

p-T210-PLK1 [cytosol]

p-T210-PLK1 [nucleoplasm]

PLK1 [cytosol]

Inferred To

PLK1 [nucleoplasm] (Bos taurus)

PLK1 [nucleoplasm] (Caenorhabditis elegans)

PLK1 [nucleoplasm] (Canis familiaris)

PLK1 [nucleoplasm] (Danio rerio)

PLK1 [nucleoplasm] (Dictyostelium discoideum)

PLK1 [nucleoplasm] (Drosophila melanogaster)

PLK1 [nucleoplasm] (Gallus gallus)

PLK1 [nucleoplasm] (Mus musculus)

PLK1 [nucleoplasm] (Plasmodium falciparum)

PLK1 [nucleoplasm] (Rattus norvegicus)

PLK1 [nucleoplasm] (Saccharomyces cerevisiae)

PLK1 [nucleoplasm] (Schizosaccharomyces pombe)

PLK1 [nucleoplasm] (Sus scrofa)

PLK1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005021.2

ZINC - World Drugs

PLK1_HUMAN

Guide to Pharmacology - Targets

2168

OpenTargets

ENSG00000166851

ZINC - FDA approved

PLK1_HUMAN

ZINC - Substances

PLK1_HUMAN

ZINC - Biogenic

PLK1_HUMAN

ZINC target

P53350

PRO

P53350

PDB

8XB9, 2OGQ, 4E67, 4X9W, 2OWB, 2V5Q, 4H71, 8BJT, 4O6W, 4WHL, 3P36, 4X9R, 4WHK, 5NFU, 4E9D, 4E9C, 4X9V, 5NJE, 7MX1, 8X72, 1UMW, 3THB, 5TA8, 8CRC, 8JOQ, 5NN1, 4O9W, 5TA6, 5NN2, 4J52, 4A4O, 6GY2, 3Q1I, 4H5X, 4J53, 4HAB, 3HIH, 1Q4K, 5NMM, 3HIK, 4RCP, 4A4L, 3C5L, 1Q4O, 5NEI, 6AX4, 3P37, 5J19, 3BZI, 3RQ7, 7MSO, 2YAC, 2OU7, 4LKL, 8JOY, 3P2W, 4O56, 3P35, 3KB7, 3P34, 2OJX, 4HY2, 4LKM, 3P2Z, 3FC2, 4WHH, 4HCO, 4DFW, 3FVH, 2RKU

ZINC - Investigational

PLK1_HUMAN

ZINC - Metabolites

PLK1_HUMAN

GeneCards

P53350

HPA

ENSG00000166851-PLK1

Ensembl

ENST00000300093, ENSP00000300093, ENSG00000166851

Pharos - Targets

P53350

ZINC - Predictions - Purchasable

PLK1_HUMAN

HMDB Protein

HMDBP01514

Interactors (94)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30307 CDC25C	8	p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S198-CDC25C [nucleoplasm] (R-HSA-156668)	0.858	8
UniProt:Q6PGQ7 BORA	3	p-S252-BORA [cytosol] (R-HSA-4086411) p-S252,S497,T501-BORA [cytosol] (R-HSA-3000330) BORA [cytosol] (R-HSA-2562607)	0.848	9
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.797	4
UniProt:O60271 SPAG9	1	SPAG9 [cytosol] (R-HSA-375975)	0.789	7
UniProt:Q2NKX8 ERCC6L	1	ERCC6L [cytosol] (R-HSA-376250)	0.788	6
UniProt:Q8IY92 SLX4	1	SLX4 [nucleoplasm] (R-HSA-5686477)	0.777	8
UniProt:Q92889 ERCC4	1	ERCC4 [nucleoplasm] (R-HSA-67445)	0.773	6
UniProt:O75170 PP6R2			0.745	7
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.737	6
UniProt:Q9NYF3 FA53C			0.725	5
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) CHEK2 [nucleoplasm] (R-HSA-113824) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784)	0.72	7
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.718	6
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.71	4
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.676	9
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.674	4
UniProt:O95251 KAT7	1	KAT7 [nucleoplasm] (R-HSA-3321823)	0.671	6
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.657	3
UniProt:O60447 EVI5			0.656	3
UniProt:Q71F23-1 CENPU			0.65	5
UniProt:O75052 CAPON			0.643	3
UniProt:Q86VG3 IFTAP			0.643	3
UniProt:P82094 TMF1	1	TMF1 [cytosol] (R-HSA-8847539)	0.643	3
UniProt:Q8TD16 BICD2	1	BICD2 [cytosol] (R-HSA-8848107)	0.643	5
UniProt:Q86WB0 ZC3HC1	2	p-S354 ZC3HC1 [nucleoplasm] (R-HSA-9724996) ZC3HC1 [nucleoplasm] (R-HSA-9724992)	0.643	5
UniProt:O15084 ANKRD28	2	ANKRD28 [cytosol] (R-HSA-5685714) ANKRD28 [nucleoplasm] (R-HSA-9686571)	0.643	3
UniProt:Q9UPW6 SATB2	2	polySUMO3-K233,K350-SATB2 [nucleoplasm] (R-HSA-4615865) SATB2 [nucleoplasm] (R-HSA-4615944)	0.643	3
UniProt:Q9UKN8 GTF3C4	1	GTF3C4 [nucleoplasm] (R-HSA-83689)	0.638	3
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.638	3
UniProt:Q9Y5Q8 GTF3C5	1	GTF3C5 [nucleoplasm] (R-HSA-83693)	0.638	3
UniProt:Q99741 CDC6	4	CDC6 [nucleoplasm] (R-HSA-68542) p-CDC6 [nucleoplasm] (R-HSA-5661317) p-CDC6 [cytosol] (R-HSA-68583) CDC6 [cytosol] (R-HSA-113566)	0.632	6
UniProt:Q60838	5	Dvl2 [cytosol] (R-MMU-4652689) Dvl2 [cytosol] (R-MMU-201694) phospho-Dvl2 [clathrin-coated endocytic vesicle] (R-MMU-5138444) phospho-Dvl2 [cytosol] (R-MMU-201706) phospho-Dvl2 [cytosol] (R-MMU-3772398)	0.632	12
UniProt:Q8TD19 NEK9	3	p-S29,T210,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984225) p-T333-NEK9 [cytosol] (R-HSA-2530600) p-S29,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984213)	0.625	5
UniProt:O75665 OFD1	1	OFD1 [cytosol] (R-HSA-380318)	0.618	4
UniProt:Q9NR09 BIRC6	2	BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713451) BIRC6(1-958)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713450)	0.602	4
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.602	7
UniProt:P54132 BLM	2	4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883) BLM [nucleoplasm] (R-HSA-174881)	0.591	4
UniProt:P30291 WEE1	3	p-WEE1 [nucleoplasm] (R-HSA-156491) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) WEE1 [nucleoplasm] (R-HSA-69253)	0.59	2
UniProt:P08107 HSP71			0.571	5
UniProt:Q9NYZ3 GTSE1	4	GTSE1 [cytosol] (R-HSA-8852264) p-S435-GTSE1 [cytosol] (R-HSA-8852316) p-S435-GTSE1 [nucleoplasm] (R-HSA-8852332) p-T513,T526-GTSE1 [cytosol] (R-HSA-8852308)	0.571	6
UniProt:A1L170 CA226			0.564	2
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.564	2
UniProt:Q5HYW2 NHSL2			0.556	3
UniProt:P49768-2 PSEN1			0.556	3
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.556	3
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q16659 MAPK6 gene	6	ub-MAPK6 [cytosol] (R-HSA-5687000) MAPK6 [cytosol] (R-HSA-5686979) p-S189 MAPK6 [cytosol] (R-HSA-5687019) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665)	0.547	2
UniProt:Q76N32 CEP68			0.544	2
UniProt:O60359 CACNG3	2	CACNG3 [plasma membrane] (R-HSA-210465) CACNG3 [endocytic vesicle membrane] (R-HSA-416853)	0.527	2
UniProt:Q5VYV7 SLX4I			0.527	2
UniProt:Q8NB46 ANR52			0.527	2
UniProt:Q71F23 CENPU	2	MLF1IP [nucleoplasm] (R-HSA-606309) MLF1IP [cytosol] (R-HSA-375315)	0.527	2
UniProt:Q6ZWJ1 STXB4			0.527	2
UniProt:Q8TEB1 DCAF11	1	DCAF11 [nucleoplasm] (R-HSA-8863251)	0.527	2
UniProt:Q9NYP9 MIS18A	1	MIS18A [nucleoplasm] (R-HSA-606299)	0.527	2
UniProt:Q99689 FEZ1			0.527	2
UniProt:Q9P286 PAK5	2	PAK7 [plasma membrane] (R-HSA-211555) PAK5 [cytosol] (R-HSA-428459)	0.527	2
UniProt:Q9BZF3 OSBPL6	1	OSBPL6 [cytosol] (R-HSA-8867534)	0.527	2
UniProt:Q9BQ83 SLX1A	1	SLX1A [nucleoplasm] (R-HSA-5686481)	0.527	2
UniProt:Q9H6R7 WDCP	2	WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol] (R-HSA-9700468) WDCP(1-680)-ALK(1061-1620) fusion [cytosol] (R-HSA-9700460)	0.527	2
UniProt:P10644 PRKAR1A	4	PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713476) PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713471) PRKAR1A [ciliary base] (R-HSA-5610408) PRKAR1A [cytosol] (R-HSA-57836)	0.527	2
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.527	2
UniProt:O60296 TRAK2	1	TRAK2 [cytosol] (R-HSA-9693815)	0.527	3
UniProt:Q86XD5 FAM131B	2	FAM131B(1-18)-BRAF(381-766) fusion [cytosol] (R-HSA-6802323) FAM131B(1-18)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802527)	0.527	2
UniProt:Q6WCQ1 MPRIP	2	MPRIP(2-1015)-RAF1(279-648) fusion [cytosol] (R-HSA-6802406) MPRIP(2-1015)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802540)	0.527	2
UniProt:O00743 PPP6C	2	PPP6C [cytosol] (R-HSA-5685719) PPP6C [nucleoplasm] (R-HSA-9686576)	0.527	2
UniProt:Q9P0K7 RAI14			0.527	3
UniProt:Q8IW35 CEP97	1	CEP97 [cytosol] (R-HSA-5626440)	0.527	2
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274)	0.527	2
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.527	2
UniProt:Q9UHD2 TBK1	5	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.527	2
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.527	2
UniProt:Q92547 TOPBP1	1	TOPBP1 [nucleoplasm] (R-HSA-5684878)	0.527	3
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.525	4
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.524	4
UniProt:Q9Y4E8 USP25	1	USP15 [cytosol] (R-HSA-2173138)	0.508	2
UniProt:Q9Y6A4 CFA20			0.508	2
UniProt:Q96R06 SPAG5			0.508	2
UniProt:Q14683 SMC1A	4	SMC1A [cytosol] (R-HSA-2484798) SMC1A [chromosome] (R-HSA-1638774) SMC1A [chromosome, centromeric region] (R-HSA-2466015) SMC1A [nucleoplasm] (R-HSA-64561)	0.508	2
UniProt:Q92949 FOXJ1			0.508	2
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.508	2
UniProt:Q9Y6Y0 NS1BP			0.508	2
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.508	2
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.508	2
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.508	2
UniProt:Q00613 HSF1	11	p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) HSF1 [cytosol] (R-HSA-3371452)	0.508	2
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.508	2
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.508	2
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.508	2
UniProt:P70399-1 TP53BP1			0.499	2
UniProt:P54727 RAD23B	2	RAD23B [nucleoplasm] (R-HSA-62590) RAD23B [cytosol] (R-HSA-8850589)	0.489	2
UniProt:P23588 EIF4B	2	p-S422-EIF4B [cytosol] (R-HSA-165773) EIF4B [cytosol] (R-HSA-72589)	0.489	3
UniProt:Q5BJF6 ODF2	1	ODF2 [cytosol] (R-HSA-380293)	0.483	2
UniProt:Q99IB8-PRO_0000045602			0.463	4

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