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PABPC1 [cytosol]
Stable Identifier
R-HSA-156803
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PABP
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Translatable mRNA Complex [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
PARN deadenylates mRNA (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)
AUF1 (hnRNP D0) is ubiquitinylated (Homo sapiens)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
AUF1 binds translation and heat shock proteins (Homo sapiens)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11940 PABPC1
Gene Names
PABPC1, PAB1, PABP1, PABPC2
Chain
chain:1-636
Reference Genes
BioGPS Gene:26986 PABPC1
COSMIC (genes):PABPC1 PABPC1
CTD Gene:26986 PABPC1
dbSNP Gene:26986 PABPC1
ENSEMBL:ENSG00000070756 PABPC1
HGNC:8554 PABPC1
KEGG Gene (Homo sapiens):26986 PABPC1
Monarch:26986 PABPC1
NCBI Gene:26986 PABPC1
OMIM:604679 PABPC1
UCSC:P11940 PABPC1
Reference Transcript
RefSeq:NM_002568.3 PABPC1
RefSeq:XM_005250861.2 PABPC1
Other Identifiers
0002510739
11536
11748097_x_at
11752278_x_at
11754246_x_at
1CVJ
1G9L
1JGN
1JH4
215157_3p_x_at
215157_x_at
26986
2701791
2766680
2K8G
2RQG
2RQH
2X04
3146787
3146788
3146789
3146791
3146793
3146794
3146795
3146796
3146799
3146801
3146802
3146805
3146806
3146807
3146809
3146812
3146814
3146815
3146819
3146820
3146821
3146822
3146823
3146824
3146825
31950_at
31951_s_at
3419625
3419626
3482124
3KTP
3KTR
3KUI
3KUJ
3KUR
3KUS
3KUT
3PKN
3PTH
45423
4F02
4F25
4F26
59809_f_at
5DX1
5DX8
5DXA
5LGP
5LGQ
5LGR
5LGS
67156
8152079
A0A024R9C1
A0A087WTT1
A_23_P82693
AAD08718
AAH15958
AAH23520
AP001205
BC015958
BC023520
CAA68428
CAA88401
CAB011536
CCDS6289
CH471060
E5RFD8
E5RGC4
E5RGH3
E5RH24
E5RHG7
E5RJB9
E5RJM8
E7EQV3
E7ERJ7
EAW91815
EAW91817
ENSG00000070756
ENSP00000313007
ENST00000318607
ENST00000318607.9
EntrezGene:26986
EntrezGene:PABPC1
GE60230
GO:0000184
GO:0000398
GO:0003674
GO:0003676
GO:0003723
GO:0003729
GO:0003730
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005681
GO:0005737
GO:0005829
GO:0005925
GO:0006378
GO:0006397
GO:0006412
GO:0006413
GO:0008022
GO:0008143
GO:0008150
GO:0008266
GO:0008380
GO:0008494
GO:0009056
GO:0009058
GO:0010494
GO:0016020
GO:0031047
GO:0032991
GO:0034641
GO:0034655
GO:0036464
GO:0043226
GO:0043488
GO:0044403
GO:0045070
GO:0045727
GO:0048255
GO:0060213
GO:0070062
GO:0071013
GO:1900153
GO:1990904
GO:2000623
H0YAS7
H0YB75
HGNC:8554
HPA045423
HPA067156
Hs.172182.2.A1_3p_s_at
ILMN_2136133
IPR000504
IPR002004
IPR003954
IPR006515
IPR012677
IPR035979
IPR036053
MIM:604679
NM_002568
NP_002559
PABPC1
PABPC1-201
PF00076
PF00658
PH_hs_0028309
SM00360
SM00361
SM00517
TC08001481.hg
U68093
U68094
U68095
U68097
U68098
U68099
U68100
U68101
U68102
U68103
U68104
U68105_s_at
UPI0000000BC4
XM_005250861
XP_005250918
Y00345
Z48501
Z48501_s_at
Participant Of
hasComponent
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol]
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol]
mRNA Cleaved by SMG6 [cytosol]
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol]
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol]
Partially Deadenylated mRNA Complex [cytosol]
ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol]
Translatable mRNA Complex [cytosol]
Uridylated partially Deadenylated mRNA Complex [cytosol]
input
AUF1 binds translation and heat shock proteins
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
Translation of ROBO3.2 mRNA initiates NMD
output
CCR4-NOT complex deadenylates mRNA
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
PARN deadenylates mRNA
Inferred To
Homologues of PABPC1 [cytosol] (Caenorhabditis elegans)
Homologues of PABPC1 [cytosol] (Dictyostelium discoideum)
Homologues of PABPC1 [cytosol] (Drosophila melanogaster)
Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
PABPC1 [cytosol] (Bos taurus)
PABPC1 [cytosol] (Caenorhabditis elegans)
PABPC1 [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Danio rerio)
PABPC1 [cytosol] (Dictyostelium discoideum)
PABPC1 [cytosol] (Drosophila melanogaster)
PABPC1 [cytosol] (Gallus gallus)
PABPC1 [cytosol] (Mus musculus)
PABPC1 [cytosol] (Plasmodium falciparum)
PABPC1 [cytosol] (Rattus norvegicus)
PABPC1 [cytosol] (Saccharomyces cerevisiae)
PABPC1 [cytosol] (Schizosaccharomyces pombe)
PABPC1 [cytosol] (Sus scrofa)
PABPC1 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_002559.2
,
XP_005250918.1
OpenTargets
ENSG00000070756
GeneCards
P11940
PRO
P11940
PDB
3KUT
,
5LGP
,
1JH4
,
5DXA
,
3KUR
,
1CVJ
,
3KTR
,
3KTP
,
1G9L
,
3KUS
,
1JGN
,
5DX8
,
4F26
,
2RQG
,
3KUJ
,
2X04
,
4F25
,
3PTH
,
5DX1
,
2RQH
,
5LGS
,
5LGR
,
2K8G
,
4F02
,
3PKN
,
3KUI
,
5LGQ
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HCJ0 TNRC6C
1
TNRC6C [cytosol]
(R-HSA-427776)
0.941
22
UniProt:Q9H074 PAIP1
1
PAIP1 [cytosol]
(R-HSA-429861)
0.91
17
UniProt:Q04637 EIF4G1
2
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
EIF4G1 [cytosol]
(R-HSA-72584)
0.835
6
UniProt:Q8IYD1 GSPT2
1
GSPT2 [cytosol]
(R-HSA-143379)
0.807
7
UniProt:O00571 DDX3X
3
DDX3X [extracellular region]
(R-HSA-6806507)
DDX3X [ficolin-1-rich granule lumen]
(R-HSA-6801273)
DDX3X [secretory granule lumen]
(R-HSA-6801275)
0.789
10
UniProt:Q99700 ATX2
0.766
6
UniProt:Q9BPZ3 PAIP2
0.74
5
UniProt:Q58A45 PAN3
1
PAN3 [cytosol]
(R-HSA-429938)
0.704
4
UniProt:Q9UPQ9 TNRC6B
1
TNRC6B [cytosol]
(R-HSA-427777)
0.656
3
UniProt:Q9UKV8 AGO2
2
AGO2 [cytosol]
(R-HSA-209723)
EIF2C2 [nucleoplasm]
(R-HSA-5578701)
0.643
6
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.589
2
UniProt:Q8NDV7 TNRC6A
2
TNRC6A [cytosol]
(R-HSA-427769)
TNRC6A [nucleoplasm]
(R-HSA-5578976)
0.564
3
UniProt:P50616 TOB1
0.558
4
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.558
5
UniProt:Q09161 NCBP1
2
NCBP1 [cytosol]
(R-HSA-162459)
NCBP1 [nucleoplasm]
(R-HSA-51469)
0.558
4
UniProt:O43432 EIF4G3
1
EIF4G3 [cytosol]
(R-HSA-1678827)
0.544
2
UniProt:Q9UL18 AGO1
2
EIF2C1 [cytosol]
(R-HSA-210616)
EIF2C1 [nucleoplasm]
(R-HSA-5578686)
0.527
4
UniProt:Q92900 UPF1
2
p-4S-UPF1 [cytosol]
(R-HSA-927856)
UPF1 [cytosol]
(R-HSA-927734)
0.527
3
UniProt:Q15366 PCBP2
2
PCBP2 [cytosol]
(R-HSA-983457)
PCBP2 [nucleoplasm]
(R-HSA-71921)
0.527
2
UniProt:Q15365 PCBP1
1
PCBP1 [nucleoplasm]
(R-HSA-71919)
0.527
2
UniProt:Q96Q15 SMG1
1
SMG1 [cytosol]
(R-HSA-927760)
0.499
2
UniProt:Q9J0X9 Q9J0X9
0.499
3
UniProt:P35568 IRS1
5
IRS1 [plasma membrane]
(R-HSA-2425392)
p-6Y-IRS1 [plasma membrane]
(R-HSA-2445090)
IRS1 [cytosol]
(R-HSA-74769)
p-Y-IRS1 [cytosol]
(R-HSA-74772)
p-Y-IRS1 [plasma membrane]
(R-HSA-198366)
0.499
2
UniProt:Q86U42 PABPN1
1
PABPN1 [nucleoplasm]
(R-HSA-72008)
0.499
2
UniProt:Q14106 TOB2
0.499
4
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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