Reactome | PABPC1 [cytosol]

PABPC1 [cytosol]

Stable Identifier

R-HSA-156803

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PABP

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External Reference Information

External Reference

UniProt:P11940 PABPC1

Gene Names

PABPC1, PAB1, PABP1, PABPC2

Chain

chain:1-636

Reference Genes

BioGPS Gene:26986 PABPC1

COSMIC (genes):PABPC1 PABPC1

CTD Gene:26986 PABPC1

dbSNP Gene:26986 PABPC1

ENSEMBL:ENSG00000070756 PABPC1

HGNC:8554 PABPC1

KEGG Gene (Homo sapiens):26986 PABPC1

Monarch:26986 PABPC1

NCBI Gene:26986 PABPC1

OMIM:604679 PABPC1

UCSC:P11940 PABPC1

Reference Transcript

Other Identifiers

0002510739

11748097_x_at

11752278_x_at

11754246_x_at

215157_3p_x_at

215157_x_at

26986

2701791

2766680

3146787

3146788

3146789

3146791

3146793

3146794

3146795

3146796

3146799

3146801

3146802

3146805

3146806

3146807

3146809

3146812

3146814

3146815

3146819

3146820

3146821

3146822

3146823

3146824

3146825

31950_at

31951_s_at

3419625

3419626

3482124

59809_f_at

8152079

A_23_P82693

GE60230

GO:0000184

GO:0000398

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0003730

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005681

GO:0005737

GO:0005829

GO:0005925

GO:0006378

GO:0006397

GO:0006412

GO:0006413

GO:0008022

GO:0008143

GO:0008150

GO:0008266

GO:0008380

GO:0008494

GO:0009056

GO:0009058

GO:0010494

GO:0016020

GO:0030027

GO:0030425

GO:0031047

GO:0031252

GO:0032991

GO:0034641

GO:0034655

GO:0036464

GO:0042995

GO:0043226

GO:0043488

GO:0044403

GO:0045070

GO:0045202

GO:0045727

GO:0048255

GO:0060213

GO:0070062

GO:0071013

GO:1900153

GO:1990124

GO:1990904

GO:2000623

Hs.172182.2.A1_3p_s_at

ILMN_2136133

PH_hs_0028309

TC08001481.hg

U68105_s_at

Z48501_s_at

Participant Of

hasComponent

input

output

Inferred To

pAbp [cytosol] (Drosophila melanogaster)

pabpc1a [cytosol] (Danio rerio)

pab-1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of PABPC1 [cytosol] (Bos taurus)

pab1 [cytosol] (Schizosaccharomyces pombe)

PABPC1 [cytosol] (Canis familiaris)

PABPC1 [cytosol] (Gallus gallus)

PABPC1 [cytosol] (Plasmodium falciparum)

PABPC1 [cytosol] (Sus scrofa)

PAB1 [cytosol] (Saccharomyces cerevisiae)

pabpc1A [cytosol] (Dictyostelium discoideum)

tbc1d10b [cytosol] (Xenopus tropicalis)

Pabpc1 [cytosol] (Mus musculus)

Pabpc1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_005250918.1, NP_002559.2

Target Pathogen

5b354852be737e166372e80f, 5b354852be737e166372e894

OpenTargets

ENSG00000070756

GeneCards

P11940

HPA

ENSG00000070756-PABPC1

Ensembl

ENSP00000313007, ENST00000318607, ENSG00000070756

PRO

P11940

PDB

1CVJ, 5DXA, 2RQH, 3KUS, 3KUJ, 2X04, 5DX1, 3KTR, 5LGS, 4F26, 5DX8, 3PTH, 1G9L, 3KTP, 3KUR, 1JGN, 5LGQ, 3PKN, 5LGR, 4F02, 2K8G, 4F25, 1JH4, 2RQG, 3KUT, 3KUI, 5LGP

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HCJ0 TNRC6C	1	TNRC6C [cytosol] (R-HSA-427776)	0.941	22
UniProt:Q9H074 PAIP1	1	PAIP1 [cytosol] (R-HSA-429861)	0.91	17
UniProt:Q04637 EIF4G1	2	EIF4G1 [cytosol] (R-HSA-72584) p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762)	0.835	6
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.807	7
UniProt:O00571 DDX3X	3	DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273) DDX3X [secretory granule lumen] (R-HSA-6801275)	0.789	10
UniProt:Q99700 ATX2			0.766	6
UniProt:Q9BPZ3 PAIP2			0.74	5
UniProt:Q58A45 PAN3	1	PAN3 [cytosol] (R-HSA-429938)	0.704	4
UniProt:Q09161 NCBP1	2	NCBP1 [cytosol] (R-HSA-162459) NCBP1 [nucleoplasm] (R-HSA-51469)	0.662	9
UniProt:Q9UPQ9 TNRC6B	1	TNRC6B [cytosol] (R-HSA-427777)	0.656	3
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) EIF2C2 [nucleoplasm] (R-HSA-5578701)	0.643	6
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.589	2
UniProt:Q8NDV7 TNRC6A	2	TNRC6A [nucleoplasm] (R-HSA-5578976) TNRC6A [cytosol] (R-HSA-427769)	0.564	3
UniProt:P50616 TOB1			0.558	4
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.558	5
UniProt:Q99700-5 Q997005			0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:O43432 EIF4G3	1	EIF4G3 [cytosol] (R-HSA-1678827)	0.544	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [cytosol] (R-HSA-210616) EIF2C1 [nucleoplasm] (R-HSA-5578686)	0.527	4
UniProt:O95503 CBX6	1	CBX6 [nucleoplasm] (R-HSA-3229071)	0.527	2
UniProt:P0DTC9 N	10	phospho-SUMO1-K62-ADPr-p-S177-Ncap [cytosol] (R-COV-9694558) phospho-SUMO1-K62-ADPr-p-S177-Ncap [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694424) phospho-ADPr-p-S177-Ncap [cytosol] (R-COV-9694254) phospho-p-S177-Ncap [cytosol] (R-COV-9694472) Ncap [cytosol] (R-COV-9694300) Ncap [plasma membrane] (R-COV-9694356) phospho-SUMO1-K62-ADPr-p-S177-Ncap [nucleolus] (R-COV-9694318) phospho-SUMO1-K62-ADPr-p-S177-Ncap [plasma membrane] (R-COV-9694764) N [cytosol] (R-COV-9694314) phospho-p-S177,S181,S185,S187,S189,S191,S195,T199,S203,S207-N [cytosol] (R-COV-9694431)	0.527	2
UniProt:Q92900 UPF1	2	p-4S-UPF1 [cytosol] (R-HSA-927856) UPF1 [cytosol] (R-HSA-927734)	0.527	3
UniProt:Q15366 PCBP2	2	PCBP2 [nucleoplasm] (R-HSA-71921) PCBP2 [cytosol] (R-HSA-983457)	0.527	2
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.527	2
UniProt:P67809 YBX1	2	YBX1 [extracellular region] (R-HSA-9017791) YBX1 [nucleoplasm] (R-HSA-72041)	0.527	2
UniProt:Q96Q15 SMG1	1	SMG1 [cytosol] (R-HSA-927760)	0.499	2
UniProt:Q9J0X9 Q9J0X9			0.499	3
UniProt:P35568 IRS1	5	p-Y-IRS1 [cytosol] (R-HSA-74772) p-Y-IRS1 [plasma membrane] (R-HSA-198366) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.499	2
UniProt:Q86U42 PABPN1	1	PABPN1 [nucleoplasm] (R-HSA-72008)	0.499	2
UniProt:Q14106 TOB2			0.499	4
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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