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Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA
Stable Identifier
R-HSA-156823
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
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Although the mechanism through which L13a prevents translation initiation has not been determined, Mazumder et al. (2003) have described four alternatives. L13a could (1) inhibit the function of eIF4F, (2) block the recruitment of the 43S preinitiation complex, (3) prevent scanning of the 43S complex to the initiation codon, or 4) interfere with joining of the 60S ribosomal subunit.
Literature References
PubMed ID
Title
Journal
Year
12588972
Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region
Seshadri, V
,
Sampath, P
,
Fox, PL
,
Mazumder, B
Mol Cell Biol
2003
Participants
Input
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol]
(Homo sapiens)
p-RPL13A [cytosol]
(Homo sapiens)
Output
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol]
(Homo sapiens)
Participates
as an event of
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Orthologous Events
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Bos taurus)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Caenorhabditis elegans)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Danio rerio)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Dictyostelium discoideum)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Drosophila melanogaster)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Plasmodium falciparum)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Rattus norvegicus)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Saccharomyces cerevisiae)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Schizosaccharomyces pombe)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Sus scrofa)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Xenopus tropicalis)
Authored
Matthews, L (2004-12-13)
Created
Gebauer, F (2004-12-20)
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