Hydrolysis of eEF1A:GTP

Stable Identifier
R-HSA-156923
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once the correct codon-anticodon match occurs between the mRNA and aa-tRNA, the decoding event triggers GTP hydrolysis on eEF1A. The resulting conformational change releases the aa-tRNA to the A-site, and GDP bound form of eEF1A is released from the ribosome.
This process is illustrated below with: an amino acyl-tRNA with an amino acid,a peptidyl-tRNA with a growing peptide and a ribosome with A,P and E sites to accommodate these two forms of tRNA.

Literature References
PubMed ID Title Journal Year
6568109 Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes

Carvalho, MD, Carvalho, JF, Merrick, WC

Arch Biochem Biophys 1984
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of 80S ribosome [cytosol]
Physical Entity
Activity
Inferred From
Authored
Created