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CCNA2 [cytosol]
Stable Identifier
R-HSA-157444
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cyclin A2, Cyclin A
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Formation of Cyclin A:Cdc2 complexes (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
CCNA:CDK1 [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
Myt-1 mediated phosphorylation of Cyclin A:Cdc2 (Homo sapiens)
CCNA:CDK1 [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
CCNA:p-T14-CDK1 [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Homo sapiens)
CCNA:p-T14-CDK1 [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
Association of Cyclin A with the APC/C (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
Degradation multiubiquitinated Cyclin A (Homo sapiens)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Formation of Cyclin A:Cdk2 complexes (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
CCNA:CDK2 [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
Translocation of Cyclin A:Cdk2 complexes to the nucleus (Homo sapiens)
CCNA:CDK2 [cytosol] (Homo sapiens)
CCNA [cytosol] (Homo sapiens)
CCNA2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20248 CCNA2
Gene Names
CCNA2, CCN1, CCNA
Chain
chain:1-432
Reference Genes
BioGPS Gene:890 CCNA2
COSMIC (genes):CCN1 CCNA2
COSMIC (genes):CCNA2 CCNA2
CTD Gene:890 CCNA2
dbSNP Gene:890 CCNA2
ENSEMBL:ENSG00000145386 CCNA2
HGNC:1578 CCNA2
KEGG:hsa:890 CCNA2
Monarch:890 CCNA2
NCBI Gene:890 CCNA2
OMIM:123835 CCNA2
UCSC:P20248 CCNA2
Reference Transcript
RefSeq:NM_001237.4 CCNA2
Other Identifiers
11722571_at
11722572_at
16979515
1943_at
203418_PM_at
203418_at
213226_PM_at
213226_at
2784114
2784115
2784116
2784117
2784119
2784120
2784121
2784122
2784123
2784125
2784128
2784129
2784130
40697_at
8102643
890
A_23_P58321
GE59759
GO:0000082
GO:0000086
GO:0000307
GO:0001939
GO:0001940
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0006275
GO:0006351
GO:0006355
GO:0007265
GO:0016538
GO:0019901
GO:0019904
GO:0031100
GO:0032355
GO:0033762
GO:0036120
GO:0043226
GO:0043687
GO:0044320
GO:0044772
GO:0044843
GO:0045893
GO:0048146
GO:0048856
GO:0051301
GO:0071314
GO:0071373
GO:0071392
GO:0071407
GO:0071456
GO:0071732
GO:0090102
GO:0097122
GO:0097124
GO:0098772
GO:1990314
GO:2000573
HMNXSV003001266
Hs.91728.1.A1_3p_at
ILMN_1786125
PH_hs_0004815
TC04001516.hg
X51688_at
g4502612_3p_at
Participates
as a candidate of
CCNA [cytosol] (Homo sapiens)
Other forms of this molecule
CCNA2 [nucleoplasm]
PolyUb-CCNA2 [nucleoplasm]
Inferred To
CycA [cytosol]
(Drosophila melanogaster)
cya-1 [cytosol]
(Caenorhabditis elegans)
ccna2 [cytosol]
(Danio rerio)
ccna2 [cytosol]
(Xenopus tropicalis)
crs1 [cytosol]
(Schizosaccharomyces pombe)
Ccna2 [cytosol]
(Mus musculus)
Ccna2 [cytosol]
(Rattus norvegicus)
CCNA2 [cytosol]
(Bos taurus)
CCNA2 [cytosol]
(Canis familiaris)
CCNA2 [cytosol]
(Gallus gallus)
CCNA2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001228.1
ENSEMBL
ENST00000274026
,
ENSP00000274026
OpenTargets
ENSG00000145386
ZINC - Substances
CCNA2_HUMAN
HPA
ENSG00000145386-CCNA2
ZINC target
P20248
PRO
P20248
Pharos - Targets
P20248
ZINC - Predictions - Purchasable
CCNA2_HUMAN
PDB
2CCH
,
6RIJ
,
6SG4
,
2WHB
,
1PKD
,
6P3W
,
4CFX
,
1OI9
,
7LUO
,
2IW6
,
1H1P
,
7QHL
,
2X1N
,
2UUE
,
2IW9
,
1OGU
,
5CYI
,
4EOL
,
1H1R
,
1H26
,
1QMZ
,
6Q6G
,
5LMK
,
1FIN
,
7ACK
,
1E9H
,
2C5O
,
4BCN
,
2UZB
,
6ATH
,
2WMA
,
2CJM
,
1OL1
,
2BPM
,
1GY3
,
1OL2
,
4EOQ
,
2IW8
,
4EOI
,
4EON
,
4EOM
,
1OKW
,
2BKZ
,
5IF1
,
1H25
,
7B5R
,
7B5L
,
4CFU
,
2C6T
,
4CFM
,
2WPA
,
3EJ1
,
2C5N
,
2C5X
,
2UZD
,
1URC
,
2CCI
,
2C4G
,
2WIH
,
2UZL
,
3F5X
,
1VYW
,
1FVV
,
2V22
,
1JSU
,
4EOO
,
5NEV
,
2WMB
,
1OKV
,
4EOJ
,
4EOR
,
1H1S
,
1H28
,
1P5E
,
4CFV
,
1OIY
,
1OIU
,
4CFN
,
6Q6H
,
2UZE
,
4BCM
,
3EOC
,
2C5V
,
4CFW
,
2WEV
,
4BCP
,
4BCK
,
2WIP
,
1H1Q
,
1JST
,
8BZO
,
4EOP
,
2WXV
,
7B7S
,
8B54
,
4EOK
,
1H24
,
6GVA
,
4EOS
,
1H27
,
7MKX
,
2WFY
,
2I40
,
8BYA
,
3EID
,
4FX3
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24941 CDK2
5
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
CDK2 [nucleoplasm]
(R-HSA-68365)
CDK2 [cytosol]
(R-HSA-157440)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
0.977
33
UniProt:P46527 CDKN1B
8
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
CDKN1B [cytosol]
(R-HSA-198622)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.967
21
UniProt:P06493 CDK1
11
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
CDK1 [cytosol]
(R-HSA-170075)
CDK1 [nucleoplasm]
(R-HSA-68889)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
0.837
9
UniProt:P38936 CDKN1A
5
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
CDKN1A [cytosol]
(R-HSA-182512)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
0.802
8
UniProt:Q9BY12 SCAPE
0.744
6
UniProt:Q9H211 CDT1
1
CDT1 [nucleoplasm]
(R-HSA-68536)
0.725
7
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.725
6
UniProt:Q99640 PKMYT1
3
PKMYT1 [cytosol]
(R-HSA-157457)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [nucleoplasm]
(R-HSA-74386)
0.725
6
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.725
6
UniProt:Q13415 ORC1
5
ORC1 [nucleoplasm]
(R-HSA-68522)
ORC1 [cytosol]
(R-HSA-113840)
p-S,T-ORC1 [nucleoplasm]
(R-HSA-68943)
PolyUb,p-S,T-ORC1 [nucleoplasm]
(R-HSA-9032189)
PolyUb,p-S,T-ORC1 [cytosol]
(R-HSA-9032195)
0.725
5
UniProt:Q08999 RBL2
2
RBL2 [nucleoplasm]
(R-HSA-389102)
p-T401,S672,S1035-RBL2 [nucleoplasm]
(R-HSA-1226084)
0.69
7
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.643
6
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.643
5
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.643
3
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.643
4
UniProt:Q6PJG2 MDEAS
0.643
5
UniProt:Q9H147 TDIF1
0.643
4
UniProt:Q00535 CDK5
4
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [nucleoplasm]
(R-HSA-8863586)
0.643
4
UniProt:Q00526 CDK3
0.643
5
UniProt:P11440 Cdk1
11
phospho-p-T161-CDK1 [nucleoplasm]
(R-MMU-170066)
phospho-p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-MMU-170074)
phospho-p-T161-CDK1 [cytosol]
(R-MMU-157415)
phospho-p-T14,Y15,T161-CDK1 [cytosol]
(R-MMU-170071)
CDK1 [cytosol]
(R-MMU-170075)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(R-MMU-170078)
phospho-p-T14-CDK1 [nucleoplasm]
(R-MMU-170045)
phospho-p-T14-CDK1 [cytosol]
(R-MMU-170064)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
phospho-p-Y4-CDK1 [cytosol]
(R-MMU-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.623
4
UniProt:P03129 VE7
0.564
2
UniProt:P09681 GIP
6
GIP(22-153) [endoplasmic reticulum lumen]
(R-HSA-400512)
GIP(22-153) [secretory granule lumen]
(R-HSA-400526)
GIP(52-93) [secretory granule lumen]
(R-HSA-400483)
GIP(54-93) [extracellular region]
(R-HSA-400542)
GIP(1-153) [endoplasmic reticulum lumen]
(R-HSA-400470)
GIP(52-93) [extracellular region]
(R-HSA-400540)
0.527
2
UniProt:P12004 PCNA
5
PCNA [nucleoplasm]
(R-HSA-68439)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
0.527
3
UniProt:P19525 EIF2AK2
5
EIF2AK2 [cytosol]
(R-HSA-168699)
p-EIF2AK2 [nucleoplasm]
(R-HSA-9836332)
p-EIF2AK2 [cytosol]
(R-HSA-9833834)
ISG15-EIF2AK2 [cytosol]
(R-HSA-9833968)
SUMO-EIF2AK2 [cytosol]
(R-HSA-9834829)
0.527
2
UniProt:Q9Y3Z3 SAMHD1
1
SAMHD1 [nucleoplasm]
(R-HSA-5624198)
0.527
2
UniProt:Q92793 CREBBP
4
CREBBP [nucleoplasm]
(R-HSA-193545)
CREBBP [cytosol]
(R-HSA-9756493)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
0.527
3
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.527
4
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.527
3
UniProt:P33552 CKS2
0.527
4
UniProt:Q9Y463 DYR1B
0.527
2
UniProt:P49918-2 CDKN1C
0.527
2
UniProt:P50613 CDK7
1
CDK7 [nucleoplasm]
(R-HSA-69218)
0.527
2
UniProt:Q8NG08 HELB
0.527
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.524
2
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