Reactome | CCNB1 [cytosol]

CCNB1 [cytosol]

Stable Identifier

R-HSA-157451

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

G2/mitotic-specific cyclin B1

Icon

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
        
        SFN dimer binds CDK1 and CCNB1 (Homo sapiens)
        
        CCNB1:CDK1 [cytosol] (Homo sapiens)
        
        CCNB1 [cytosol] (Homo sapiens)
        
        SFN Dimer:CCNB1:CDK1 [cytosol] (Homo sapiens)
        
        CCNB1:CDK1 [cytosol] (Homo sapiens)
        
        CCNB1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14635 CCNB1

Gene Names

CCNB1, CCNB

Chain

chain:1-433

Reference Genes

BioGPS Gene:891 CCNB1

COSMIC (genes):CCNB1 CCNB1

CTD Gene:891 CCNB1

dbSNP Gene:891 CCNB1

ENSEMBL:ENSG00000134057 CCNB1

ENSEMBL_homo_sapiens_GENE:ENSG00000134057.15 CCNB1

HGNC:1579 CCNB1

KEGG Gene (Homo sapiens):891 CCNB1

Monarch:891 CCNB1

NCBI Gene:891 CCNB1

OMIM:123836 CCNB1

UCSC:P14635 CCNB1

Reference Transcript

RefSeq:NM_031966.3 CCNB1

Other Identifiers

11723939_a_at

16985599

1945_at

214710_PM_s_at

214710_s_at

228729_PM_at

228729_at

2813416

2813417

2813418

2813419

2813421

2813422

2813423

2813424

2813425

2813427

2813429

2813432

2813434

2813435

2813436

2813437

34736_at

63638_at

8105828

891

A_33_P3401621

GE57886

GO:0000086

GO:0000278

GO:0000922

GO:0000940

GO:0001701

GO:0005113

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005759

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006091

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007080

GO:0010971

GO:0016020

GO:0016538

GO:0019901

GO:0023052

GO:0043226

GO:0044389

GO:0044772

GO:0045787

GO:0045931

GO:0048146

GO:0048856

GO:0051301

GO:0051987

GO:0061575

GO:0090266

GO:0097125

GO:0098772

GO:0140014

GO:1905448

HMNXSV003039343

Hs.23960.0.S1_3p_at

Hs.23960.2.S1_3p_a_at

ILMN_1712803

M25753_at

PH_hs_0002110

TC05000298.hg

TC05002418.hg

Participates

as an output of

MITF-M-dependent CCNB1 gene expression (Homo sapiens)

as a component of

as a member of

CCNB [cytosol] (Homo sapiens)

Other forms of this molecule

CCNB1 [nucleoplasm]

p-4S-CCNB1 [cytosol]

p-4S-CCNB1 [nucleoplasm]

Inferred To

CycB [cytosol] (Drosophila melanogaster)

cycD [cytosol] (Dictyostelium discoideum)

Ccnb1 [cytosol] (Mus musculus)

Ccnb1 [cytosol] (Rattus norvegicus)

Homologues of CCNB1 [cytosol] (Caenorhabditis elegans)

Homologues of CCNB1 [cytosol] (Dictyostelium discoideum)

ccnb1.2 [cytosol] (Xenopus tropicalis)

cycB [cytosol] (Dictyostelium discoideum)

ccnb1 [cytosol] (Danio rerio)

cyb-1 [cytosol] (Caenorhabditis elegans)

cycA [cytosol] (Dictyostelium discoideum)

CCNB1 [cytosol] (Bos taurus)

CCNB1 [cytosol] (Canis familiaris)

CCNB1 [cytosol] (Sus scrofa)

Ghost homologue of CCNB1 [cytosol] (Gallus gallus)

cyb-2.2 [cytosol] (Caenorhabditis elegans)

cyb-2.1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_114172.1

OpenTargets

ENSG00000134057

ZINC - Substances

CCNB1_HUMAN

GeneCards

P14635

HPA

ENSG00000134057-CCNB1

Ensembl

ENST00000505500, ENSG00000134057, ENSP00000424588, ENSP00000256442, ENST00000256442

ZINC target

P14635

PRO

P14635

Pharos - Targets

P14635

ZINC - Predictions - Purchasable

CCNB1_HUMAN

PDB

5HQ0, 4Y72, 8TAU, 5LQF, 2JGZ, 6GU3, 7NJ0, 6GU4, 6GU2, 8TAR, 4YC3, 2B9R

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.976	28
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.886	8
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.877	11
UniProt:Q99640 PKMYT1	3	PKMYT1 [cytosol] (R-HSA-157457) p-PKMYT1 [nucleoplasm] (R-HSA-162650) PKMYT1 [nucleoplasm] (R-HSA-74386)	0.867	8
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.744	6
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.731	5
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.643	4
UniProt:P33552 CKS2			0.643	4
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	4
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.59	2
UniProt:O75618-1 DEDD			0.576	3
UniProt:Q12778 FOXO1	5	p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158)	0.571	2
UniProt:Q9NPG2 NGB	1	NGB [cytosol] (R-HSA-5216004)	0.527	2
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.527	3
UniProt:Q9NPC3 CIP1			0.527	2
UniProt:Q8N4Q0 PTGR3			0.527	2
UniProt:Q9H5V7 IKZF5			0.527	2
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.527	2
UniProt:O60256 KPRB			0.527	2
UniProt:Q9NVD7 PARVA	1	PARVA [cytosol] (R-HSA-432848)	0.527	2
UniProt:Q13635 PTCH1	4	PTCH1 [plasma membrane] (R-HSA-445133) ub-PTCH1 [endocytic vesicle membrane] (R-HSA-5632520) ub-PTCH1 [ciliary membrane] (R-HSA-5632517) PTCH1 [ciliary membrane] (R-HSA-5610415)	0.499	2
UniProt:Q9UM11 FZR1	4	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193)	0.483	3
UniProt:Q14674 ESPL1	4	ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.462	2

Cite Us!