NEXT2 is cleaved to produce NICD2

Stable Identifier
R-HSA-157640
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NEXT2 is cleaved to produce NICD2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NEXT2 fragment of NOTCH2 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD2 into the cytosol (Saxena et al. 2001, De Strooper et al. 1999, Schroeter et al. 1998, Fortini 2002).

Literature References
PubMed ID Title Journal Year
11518718 Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

Saxena, MT, Schroeter, EH, Mumm, JS, Kopan, R

J Biol Chem 2001
24842903 Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins

Groot, AJ, Habets, R, Yahyanejad, S, Hodin, CM, Reiss, K, Saftig, P, Theys, J, Vooijs, M

Mol. Cell. Biol. 2014
12209127 Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

Fortini, ME

Nat Rev Mol Cell Biol 2002
9620803 Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Schroeter, EH, Kisslinger, JA, Kopan, R

Nature 1998
10206645 A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

De Strooper, B, Annaert, W, Cupers, P, Saftig, P, Craessaerts, K, Mumm, JS, Schroeter, EH, Schrijvers, V, Wolfe, MS, Ray, WJ, Goate, A, Kopan, R

Nature 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
gamma-secretase complex [plasma membrane]
Activity
aspartic-type endopeptidase activity (0004190)
Inferred From
Gamma-secretase complex cleaves mNEXT2 (Homo sapiens)
Authored
Jassal, B  (2004-12-15)
Reviewed
Boyle, S  (2013-04-25)
Ilagan, MXG  (2013-04-25)
Created
Jassal, B  (2004-12-21)
Cite Us!