Reactome | CDC25C [cytosol]

CDC25C [cytosol]

Stable Identifier

R-HSA-157879

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cdc25C, M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C), M-phase inducer phosphatase 3 , Dual specificity phosphatase Cdc25C

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P30307 CDC25C

Gene Names

CDC25C

Chain

initiator methionine:, chain:2-473

Reference Genes

BioGPS Gene:995 CDC25C

COSMIC (genes):CDC25C CDC25C

CTD Gene:995 CDC25C

dbSNP Gene:995 CDC25C

ENSEMBL:ENSG00000158402 CDC25C

ENSEMBL_homo_sapiens_GENE:ENSG00000158402.21 CDC25C

HGNC:1727 CDC25C

KEGG Gene (Homo sapiens):995 CDC25C

Monarch:995 CDC25C

NCBI Gene:995 CDC25C

OMIM:157680 CDC25C

UCSC:P30307 CDC25C

Reference Transcript

Other Identifiers

11720835_a_at

11748104_a_at

1584_at

17000439

205167_PM_s_at

205167_s_at

217010_PM_s_at

217010_s_at

2877379

2877380

2877381

2877382

2877384

2877387

2877388

2877390

2877392

2877393

2877396

2877397

2877399

2877400

2877402

2877403

2877404

2877406

2877407

2877410

2877411

8114425

995

A_23_P70249

GE57938

GO:0000079

GO:0000086

GO:0000278

GO:0003824

GO:0004721

GO:0004725

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005758

GO:0005829

GO:0006470

GO:0007049

GO:0007088

GO:0007283

GO:0008283

GO:0010971

GO:0016787

GO:0019901

GO:0022414

GO:0036211

GO:0043226

GO:0048471

GO:0050699

GO:0051301

GO:0110032

GO:0140014

GO:0140096

GO:1902751

HMNXSV003054256

Hs.656.2.S1_3p_a_at

ILMN_1725260

ILMN_2294431

ILMN_2407619

M34065_at

TC05001829.hg

TC05003257.hg

Z29077_xpt1_at

g12408659_3p_a_at

Participates

as a component of

as an input of

Other forms of this molecule

p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]

p-S191-CDC25C [nucleoplasm]

p-S216-CDC25C [cytosol]

p-S216-CDC25C [nucleoplasm]

CDC25C [nucleoplasm]

p-S198-CDC25C [cytosol]

p-S198-CDC25C [nucleoplasm]

Inferred To

cdc-25.4 [cytosol] (Caenorhabditis elegans)

CDC25C [cytosol] (Bos taurus)

CDC25C [cytosol] (Canis familiaris)

CDC25C [cytosol] (Sus scrofa)

cdc25 [cytosol] (Dictyostelium discoideum)

cdc25 [cytosol] (Schizosaccharomyces pombe)

twe [cytosol] (Drosophila melanogaster)

Cdc25c [cytosol] (Mus musculus)

Cdc25c [cytosol] (Rattus norvegicus)

cdc-25.3 [cytosol] (Caenorhabditis elegans)

stg [cytosol] (Drosophila melanogaster)

Homologues of CDC25C [cytosol] (Caenorhabditis elegans)

Homologues of CDC25C [cytosol] (Drosophila melanogaster)

Homologues of CDC25C [cytosol] (Sus scrofa)

MIH1 [cytosol] (Saccharomyces cerevisiae)

cdc-25.1 [cytosol] (Caenorhabditis elegans)

cdc-25.2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001781.2, NP_001274511.1, NP_073720.1, XP_011542064.1, NP_001305027.1

OpenTargets

ENSG00000158402

ZINC - Substances

MPIP3_HUMAN

GeneCards

P30307

HPA

ENSG00000158402-CDC25C

ZINC target

P30307

Ensembl

ENSP00000424795, ENSG00000158402, ENSP00000321656, ENST00000415130, ENST00000514555, ENST00000513970, ENSP00000392631, ENST00000323760, ENSP00000425470

PRO

P30307

Pharos - Targets

P30307

ZINC - Predictions - Purchasable

MPIP3_HUMAN

HMDB Protein

HMDBP08921

PDB

3OP3, 3BZI, 5M37, 5M36, 5M35, 2OJX

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.886	8
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.858	8
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.837	7
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.837	7
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.773	6
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.669	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.643	4
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.643	3
UniProt:O14757 CHEK1	3	CHEK1 [cytosol] (R-HSA-205285) CHEK1 [nucleoplasm] (R-HSA-113826) p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838)	0.623	2
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.623	3
UniProt:Q14738 PPP2R5D	2	PPP2R5D [nucleoplasm] (R-HSA-3008956) PPP2R5D [cytosol] (R-HSA-3008950)	0.589	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q9Y250 LZTS1			0.499	2

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