prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer

Stable Identifier
R-HSA-158218
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Prekallikrein (PK) associates specifically with kininogen (HK) on cell surfaces. In vivo, this reaction may occur primarily on the surfaces of endothelial cells in response to platelet activation (Lin et al. 1997; Motta et al. 1998; Mahdi et al. 2003).

Literature References
PubMed ID Title Journal Year
3521732 Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats

Chung, DW, Fujikawa, K, McMullen, BA, Davie, EW

Biochemistry 1986
9226169 High molecular weight kininogen peptides inhibit the formation of kallikrein on endothelial cell surfaces and subsequent urokinase-dependent plasmin formation

Lin, Y, Harris, RB, Yan, W, McCrae, KR, Zhang, H, Colman, RW

Blood 1997
12944405 The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells

Mahdi, F, Shariat-Madar, Z, Schmaier, AH

J Biol Chem 2003
9427705 High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation

Motta, G, Rojkjaer, R, Hasan, AA, Cines, DB, Schmaier, AH

Blood 1998
Participants
Participant Of
Orthologous Events
Authored
Created