factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)

Stable Identifier
R-HSA-158333
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
activation of factor IX (factor XIa catalyst)
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Factor XIa, bound to platelet glycoprotein (GP) Ib:IX:V on the platelet cell surface, catalyzes the formation of activated factor IX with high efficiency in a reaction that requires Ca++. The amino terminal part of the heavy chain of factor IX, the factor IX activation peptide, is released. (This peptide has no known function.)

Literature References
PubMed ID Title Journal Year
681330 Human blood coagulation factor IX. Purification, properties, and mechanism of activation by activated factor XI.

Osterud, B, Bouma, BN, Griffin, JH

J Biol Chem 1978
11342438 Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential

Gailani, D, Ho, D, Sun, MF, Cheng, Q, Walsh, PN

Blood 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of factor XIa:GPIb:GPIX:GPV complex [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Created