kallikrein + C1Inh -> kallikrein:C1Inh

Stable Identifier
R-HSA-158399
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Activated kallikrein binds to C1Inh (plasma protease C1 inhibitor) (Bock et al. 1986), forming a stable and enzymatically inactive complex. This reaction appears to be the major means by which kallikrein is inactivated (kallikrein can also be inactivated by binding to alpha2-macroglobulin) (Harpel et al. 1985; Ratnoff et al. 1969).

Literature References
PubMed ID Title Journal Year
2579948 Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes

Harpel, PC, Lewin, MF, Kaplan, AP

J Biol Chem 1985
3756141 Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization

Bock, SC, Skriver, K, Nielsen, E, Thogersen, HC, Wiman, B, Donaldson, VH, Eddy, RL, Marrinan, J, Radziejewska, E, Huber, R, Magnusson, S

Biochemistry 1986
4178758 The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor

Ratnoff, OD, Pensky, J, Ogston, D, Naff, GB

J Exp Med 1969
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