Reactome | Release of the SLBP independent Histone mRNA from the NPC

Release of the SLBP independent Histone mRNA from the NPC

Stable Identifier

R-HSA-158484

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

Locations in the PathwayBrowser

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Summation

At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm (Hung et al.2010, Lindtner et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
22732409	Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing Grzybowska, EA	Biochem. Biophys. Res. Commun.	2012
12003494	An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element Lindtner, S, Felber, BK, Kjems, J	RNA	2002

Participants

Input

Output

Participant Of

hasEvent

Transport of the SLBP independent Mature mRNA

Event Information

Go Biological Process

mRNA export from nucleus (0006406)

This entity is regulated by

Requirements

Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'

Authored

Gillespie, ME (2005-01-27)