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PLG(20-810) [extracellular region]
Stable Identifier
R-HSA-158701
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
PLG, plasminogen
Icon
Locations in the PathwayBrowser for interactor UniProt:Q3SYB3 FX4L6
Expand all
Hemostasis (Homo sapiens)
Dissolution of Fibrin Clot (Homo sapiens)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Homo sapiens)
PLG(20-810) [extracellular region] (Homo sapiens)
crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Homo sapiens)
PLG(20-810) [extracellular region] (Homo sapiens)
histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Homo sapiens)
PLG(20-810) [extracellular region] (Homo sapiens)
histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Homo sapiens)
PLG(20-810) [extracellular region] (Homo sapiens)
plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Homo sapiens)
PLG(20-810) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00747 PLG
Gene Names
PLG
Chain
signal peptide:1-19, chain:20-810, chain:20-580, peptide:20-97, chain:79-466, chain:98-580, chain:581-810
Reference Genes
BioGPS Gene:5340 PLG
COSMIC (genes):PLG PLG
CTD Gene:5340 PLG
dbSNP Gene:5340 PLG
ENSEMBL:ENSG00000122194 PLG
ENSEMBL_homo_sapiens_GENE:ENSG00000122194.20 PLG
HGNC:9071 PLG
KEGG Gene (Homo sapiens):5340 PLG
Monarch:5340 PLG
NCBI Gene:5340 PLG
OMIM:173350 PLG
UCSC:P00747 PLG
Reference Transcript
RefSeq:NM_000301.3 PLG
Other Identifiers
11720476_a_at
11720477_a_at
11746278_a_at
11757403_x_at
17014459
209977_PM_at
209977_at
209978_PM_s_at
209978_s_at
230931_PM_at
230931_at
2492660
2492661
2492671
2492678
2492682
2498398
2498404
2498408
2498411
2563051
2563054
2563060
2563067
2563068
2934684
2934685
2934687
2934688
2934690
2934695
2934698
2934701
2934706
2934708
2934709
2934710
2934712
2934713
2934714
2934718
2934721
2934722
2934724
2934725
2934726
2934727
2934729
2934730
2934731
2934732
2934733
2934734
2934735
2934736
2934737
2934738
2982686
2982687
2982690
2982692
2982734
2982744
2982787
36646_at
5340
8043367
8053602
8123259
A_23_P30693
A_32_P206123
GE59666
GO:0002020
GO:0002376
GO:0003824
GO:0004175
GO:0004252
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006508
GO:0007155
GO:0007596
GO:0007599
GO:0008233
GO:0008236
GO:0008285
GO:0009897
GO:0009986
GO:0010812
GO:0016787
GO:0019899
GO:0019900
GO:0019904
GO:0022414
GO:0022617
GO:0023052
GO:0030154
GO:0030198
GO:0030312
GO:0031012
GO:0031093
GO:0031410
GO:0034185
GO:0042060
GO:0042246
GO:0042730
GO:0043226
GO:0043536
GO:0045445
GO:0046716
GO:0048771
GO:0048856
GO:0048870
GO:0051087
GO:0051702
GO:0051918
GO:0051919
GO:0060707
GO:0060716
GO:0062023
GO:0070062
GO:0071674
GO:0072562
GO:0098685
GO:0098978
GO:0099183
GO:0140096
GO:1990405
GO:2000048
Hs.81086.1.A1_3p_at
ILMN_1698587
ILMN_1714446
M34276_at
M86873_s_at
PH_hs_0022570
g190025_3p_at
Participates
as a component of
fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region] (Homo sapiens)
histidine-rich glycoprotein:plasminogen [extracellular region] (Homo sapiens)
as an input of
crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Homo sapiens)
plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Homo sapiens)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Homo sapiens)
histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Homo sapiens)
as an output of
histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Homo sapiens)
Other forms of this molecule
PLG(20-810) [plasma membrane]
PLG(1-810) [extracellular region]
PLG(20-810) [platelet alpha granule lumen]
PLG(20-580) [extracellular region]
PLG(581-810) [extracellular region]
Inferred To
PLG(20-810) [extracellular region]
(Bos taurus)
PLG(20-810) [extracellular region]
(Sus scrofa)
PLG(20-810) [extracellular region]
(Xenopus tropicalis)
PLG [extracellular region]
(Canis familiaris)
PLG [extracellular region]
(Gallus gallus)
Plg [extracellular region]
(Mus musculus)
Plg [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_000292.1
ZINC - World Drugs
PLMN_HUMAN
Guide to Pharmacology - Targets
2394
OpenTargets
ENSG00000122194
ZINC - FDA approved
PLMN_HUMAN
ZINC - Substances
PLMN_HUMAN
ZINC target
P00747
ZINC - Biogenic
PLMN_HUMAN
PRO
P00747
PDB
1L4D
,
1HPJ
,
4A5T
,
1RJX
,
1CEA
,
4DUR
,
1DDJ
,
1CEB
,
8F7U
,
1PMK
,
1PKR
,
8F7V
,
4DCB
,
1QRZ
,
6D3Z
,
1BUI
,
6D40
,
2DOI
,
7E50
,
7UAH
,
6OQK
,
2DOH
,
1BML
,
4CIK
,
6D3Y
,
1KI0
,
6Q1U
,
1KRN
,
1L4Z
,
6OQJ
,
2KNF
,
5UGG
,
2L0S
,
6D3X
,
1B2I
,
7THS
,
6UZ5
,
5HPG
,
1PK4
,
3UIR
,
1HPK
,
4DUU
,
5UGD
,
6OG4
,
2PK4
,
1I5K
,
6UZ4
ZINC - Investigational
PLMN_HUMAN
ZINC - Metabolites
PLMN_HUMAN
GeneCards
P00747
HPA
ENSG00000122194-PLG
Ensembl
ENSG00000122194
,
ENSP00000308938
,
ENST00000308192
Pharos - Targets
P00747
ZINC - Predictions - Purchasable
PLMN_HUMAN
Orphanet
15108
HMDB Protein
HMDBP01984
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P75391 ODPB
0.83
11
UniProt:P75390 ODPA
0.656
5
UniProt:P75392 ODP2
0.656
5
UniProt:Q6V4L9 Q6V4L9
0.558
2
UniProt:Q99SU7 SAK
0.558
7
UniProt:Q6V4L1 Q6V4L1
0.558
2
UniProt:Q6V4L5 Q6V4L5
0.558
2
UniProt:Q6V4L4 Q6V4L4
0.558
2
UniProt:P28300-PRO_0000018520 LOX
0.558
2
IntAct:EBI-25850457 CCSB
0.556
3
UniProt:Q3SYB3 FX4L6
0.556
3
UniProt:Q8N4S9 MALD2
0.544
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.527
2
UniProt:P07251 ATP1
3
ATP1 precursor [mitochondrial intermembrane space]
(R-SCE-1252145)
ATP1 precursor [cytosol]
(R-SCE-1252120)
ATP5F1A [mitochondrial matrix]
(R-SCE-164575)
0.524
2
UniProt:P75393 DLDH
0.524
3
UniProt:P38077
1
ATP3 [mitochondrial matrix]
(R-SCE-164577)
0.524
2
UniProt:Q12165 ATPD
0.524
2
UniProt:P21306 ATP5E
0.524
2
UniProt:P00830 ATP2
5
ATP2 [mitochondrial inner membrane]
(R-SCE-1267966)
ATP2 precursor [mitochondrial inner membrane]
(R-SCE-1252057)
ATP2 precursor [mitochondrial intermembrane space]
(R-SCE-1252202)
ATP2 precursor [cytosol]
(R-SCE-1252203)
ATP5F1B [mitochondrial matrix]
(R-SCE-164576)
0.524
2
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