Reactome: A Curated Pathway Database

histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen

Stable Identifier
R-HSA-158721
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Plasminogen reversibly binds histidine-rich glycoprotein (HRG). The resulting complex interacts poorly with fibrin, suggesting that HRG might have an anti-fibrinolytic (clot-stabilizing) effect in vivo (Lijnen et al. 1980). Consistent with this suggestion, individuals with chronically reduced plasma HRG concentrations are susceptible to thrombosis (Shigekiyo et al. 1998).

Literature References
Participants
Participant Of
Orthologous Events