crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)

Stable Identifier
R-HSA-158747
Type
Reaction
Species
Homo sapiens
Compartment
Summation

Once plasmin has been activated, in the initial stage of the fibrinolysis process, it can catalyze the conversion of fibrin-bound tissue plasminogen activator (one-chain) to its more active two-chain form, increasing the rate at which additional plasminogen molecules can be activated.

Literature References
PubMed ID Title Journal Year
2496749 The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site

Boose, JA, Kuismanen, E, Gerard, R, Sambrook, J, Gething, MJ

Biochemistry 1989
2962641 Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin

Higgins, DL, Vehar, GA

Biochemistry 1987
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Plasmin [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored